Scientific World Model

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Showing 1–50 of 160 pages matching "tau"

⚙️ Neuroimmune Response in 4R-Tauopathies: Cross-Disease ComparisonKG

mechanism · 5,083 words · 26 hyp46 ana14 exp

⚙️ Tau Spreading MechanismKG

mechanism · 4,818 words · 18 hyp35 ana6 exp

⚙️ Tau Strain Diversity and Conformational Templating in TauopathiesKG

mechanism · 4,415 words · 15 hyp36 ana8 exp

⚙️ psp-tauopathyKG

mechanism · 4,377 words · 13 hyp36 ana28 exp

⚙️ TauopathiesKG

mechanism · 4,072 words · 48 hyp47 ana24 exp

⚙️ Braak Staging and Tau Propagation PathwayKG

mechanism · 3,941 words · 30 hyp40 ana3 exp

⚙️ Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease ComparisonKG

mechanism · 3,560 words · 13 hyp48 ana5 exp

⚙️ tau-hyperphosphorylationKG

mechanism · 3,543 words · 31 ana5 exp

⚙️ Tau Pathology Pathway in Frontotemporal DementiaKG

mechanism · 3,486 words · 24 hyp46 ana8 exp

⚙️ Kynurenine Pathway Dysregulation in 4R-TauopathiesKG

mechanism · 3,467 words · 21 hyp39 ana4 exp

⚙️ Sleep and Glymphatic Tau Clearance in TauopathiesKG

mechanism · 3,345 words · 27 hyp47 ana3 exp

⚙️ Granulovacuolar Bodies: Neuronal Defense Mechanism Against Tau PathologyKG

mechanism · 3,313 words · 23 hyp41 ana6 exp

⚙️ Tau PathologyKG

mechanism · 3,310 words · 66 hyp58 ana37 exp

⚙️ 4R Tau in Corticobasal DegenerationKG

mechanism · 3,291 words · 9 hyp36 ana4 exp

⚙️ Oxidative Stress Response in 4R-TauopathiesKG

mechanism · 3,287 words · 13 hyp34 ana18 exp

⚙️ cortisol-tau-pathwayKG

mechanism · 3,248 words · 44 hyp45 ana14 exp

⚙️ OTULIN-Tau Regulation PathwayKG

mechanism · 3,232 words · 27 hyp37 ana3 exp

⚙️ FTD Tau Subtypes Comparison: 3R vs 4R TauopathiesKG

mechanism · 3,179 words · 3 hyp37 ana23 exp

⚙️ 4R Tauopathy MechanismsKG

mechanism · 3,168 words · 9 hyp35 ana7 exp

⚙️ Tau Network Propagation Hypothesis (Prion-Like Spread)KG

mechanism · 3,148 words · 9 hyp34 ana

⚙️ PP2A Tau Phosphatase PathwayKG

mechanism · 3,148 words · 21 hyp40 ana1 exp

⚙️ gut-brain-axis-tauopathyKG

mechanism · 3,109 words · 24 hyp43 ana5 exp

⚙️ Astrocyte Reactivity in 4R-TauopathiesKG

mechanism · 3,071 words · 127 hyp66 ana22 exp

⚙️ Tau Kinase Signaling Cascade in Alzheimer's DiseaseKG

mechanism · 3,059 words · 122 hyp49 ana56 exp

⚙️ Tanycytes: A Novel Tau Clearance Pathway from Brain to BloodKG

mechanism · 3,058 words · 38 hyp50 ana3 exp

⚙️ MAPT→Tau→Aggregation→PSP Causal ChainKG

mechanism · 3,015 words · 5 hyp35 ana28 exp

⚙️ Tau Pathology Alters Oligodendrocyte Gene Methylation in [Alzheimer's Disease](/diseases/alzheimers-disease)KG

mechanism · 3,013 words · 67 hyp53 ana48 exp

⚙️ TauopathyKG

mechanism · 3,007 words · 61 hyp52 ana17 exp

⚙️ Tau Immunotherapy MechanismsKG

mechanism · 2,983 words · 4 hyp33 ana8 exp

⚙️ Tau Proteostasis and Clearance Across 4R-TauopathiesKG

mechanism · 2,932 words · 40 hyp49 ana19 exp

⚙️ Cell Death Pathways in 4R-TauopathiesKG

mechanism · 2,854 words · 15 hyp35 ana3 exp

⚙️ Tau Seeding and Propagation PathwayKG

mechanism · 2,827 words · 41 hyp42 ana6 exp

⚙️ Ganglioside and Membrane Lipid Raft Dysfunction in 4R-TauopathiesKG

mechanism · 2,815 words · 45 hyp43 ana23 exp

⚙️ Neurogenesis Impairment in 4R-TauopathiesKG

mechanism · 2,808 words · 31 hyp45 ana6 exp

⚙️ Computational Models of Tau Propagation in Progressive Supranuclear PalsyKG

mechanism · 2,788 words · 17 hyp35 ana36 exp

⚙️ Neural Circuit Dysfunction in 4R-TauopathiesKG

mechanism · 2,726 words · 12 hyp39 ana1 exp

⚙️ oga-inhibition-tauKG

mechanism · 2,692 words · 32 hyp40 ana4 exp

⚙️ Brain Region Vulnerability in 4R-TauopathiesKG

mechanism · 2,646 words · 211 hyp65 ana20 exp

⚙️ Tau Kinase-Phosphatase Balance in Alzheimer's DiseaseKG

mechanism · 2,631 words · 30 hyp44 ana49 exp

⚙️ Ganglioside Sialylation in Tau InternalizationKG

mechanism · 2,597 words · 21 hyp36 ana19 exp

⚙️ JAK-STAT and Cytokine Signaling in 4R-TauopathiesKG

mechanism · 2,596 words · 74 hyp37 ana7 exp

⚙️ Tau Post-Translational Modifications in 4R-TauopathiesKG

mechanism · 2,594 words · 3 hyp34 ana4 exp

⚙️ Computational Tau Propagation Model Validation with PET ImagingKG

mechanism · 2,593 words · 16 hyp37 ana14 exp

⚙️ AD-FTD Tau-TDP-43 Overlap: Mechanism ComparisonKG

mechanism · 2,557 words · 21 hyp41 ana22 exp

⚙️ Metabolic Dysfunction in 4R-TauopathiesKG

mechanism · 2,556 words · 55 hyp58 ana5 exp

⚙️ TNAP/P2X7R/CTCF Signaling Axis in TauopathiesKG

mechanism · 2,538 words · 53 hyp36 ana5 exp

⚙️ Tau Pathology PathwayKG

mechanism · 2,521 words · 27 hyp43 ana7 exp

⚙️ Tau Propagation MechanismsKG

mechanism · 2,487 words · 15 hyp37 ana7 exp

⚙️ Computational Tau Spreading Models in Progressive Supranuclear PalsyKG

mechanism · 2,468 words · 15 hyp34 ana33 exp

⚙️ Tau Propagation and Seeding in Progressive Supranuclear PalsyKG

mechanism · 2,464 words · 16 hyp39 ana22 exp