Scientific World Model

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Showing 1–50 of 343 pages matching "tau"

🧪 PI-2620 Tau PET in PSPKG

clinical · 5,625 words · 4 hyp3 ana7 exp

⚙️ Neuroimmune Response in 4R-Tauopathies: Cross-Disease ComparisonKG

mechanism · 5,083 words · 35 hyp46 ana14 exp

📊 p-tau-217KG

biomarker · 4,980 words · 9 hyp2 ana2 exp

⚙️ Tau Spreading MechanismKG

mechanism · 4,818 words · 22 hyp35 ana6 exp

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic ComparisonKG

hypothesis · 4,630 words · 17 hyp16 ana11 exp

💊 Melatonin for Tauopathy: Comprehensive Evidence SynthesisKG

therapeutic · 4,539 words · 39 hyp35 ana26 exp

⚙️ Tau Strain Diversity and Conformational Templating in TauopathiesKG

mechanism · 4,415 words · 19 hyp36 ana8 exp

⚙️ psp-tauopathyKG

mechanism · 4,377 words · 18 hyp37 ana28 exp

💊 lithium-tauopathyKG

therapeutic · 4,282 words · 7 hyp5 ana3 exp

⚙️ TauopathiesKG

mechanism · 4,072 words · 65 hyp48 ana24 exp

⚙️ Braak Staging and Tau Propagation PathwayKG

mechanism · 3,941 words · 33 hyp40 ana3 exp

💊 rapamycin-tauopathyKG

therapeutic · 3,805 words · 59 hyp37 ana8 exp

🧪 E2814 — Phase 2 for 4R-TauopathyKG

clinical · 3,678 words · 14 hyp5 ana4 exp

⚙️ Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease ComparisonKG

mechanism · 3,560 words · 16 hyp48 ana5 exp

⚙️ tau-hyperphosphorylationKG

mechanism · 3,543 words · 3 hyp31 ana5 exp

⚙️ Tau Pathology Pathway in Frontotemporal DementiaKG

mechanism · 3,486 words · 28 hyp47 ana8 exp

⚙️ Kynurenine Pathway Dysregulation in 4R-TauopathiesKG

mechanism · 3,467 words · 24 hyp39 ana4 exp

⚙️ Sleep and Glymphatic Tau Clearance in TauopathiesKG

mechanism · 3,345 words · 27 hyp47 ana3 exp

⚙️ Granulovacuolar Bodies: Neuronal Defense Mechanism Against Tau PathologyKG

mechanism · 3,313 words · 18 hyp40 ana6 exp

⚙️ Tau PathologyKG

mechanism · 3,310 words · 139 hyp62 ana37 exp

⚙️ 4R Tau in Corticobasal DegenerationKG

mechanism · 3,291 words · 12 hyp36 ana4 exp

⚙️ Oxidative Stress Response in 4R-TauopathiesKG

mechanism · 3,287 words · 20 hyp34 ana18 exp

⚙️ cortisol-tau-pathwayKG

mechanism · 3,248 words · 53 hyp45 ana14 exp

Litronesib (LY317615/Enzastaurin)KG

entity · 3,236 words · 1 hyp1 ana5 exp

⚙️ OTULIN-Tau Regulation PathwayKG

mechanism · 3,232 words · 30 hyp37 ana3 exp

⚙️ FTD Tau Subtypes Comparison: 3R vs 4R TauopathiesKG

mechanism · 3,179 words · 6 hyp38 ana23 exp

⚙️ 4R Tauopathy MechanismsKG

mechanism · 3,168 words · 14 hyp35 ana7 exp

⚙️ Tau Network Propagation Hypothesis (Prion-Like Spread)KG

mechanism · 3,148 words · 9 hyp34 ana

⚙️ PP2A Tau Phosphatase PathwayKG

mechanism · 3,148 words · 21 hyp37 ana1 exp

⚙️ gut-brain-axis-tauopathyKG

mechanism · 3,109 words · 24 hyp43 ana5 exp

👤 Maria Stamelou — PSP and Tauopathy Researcher

researcher · 3,075 words · 11 hyp3 ana9 exp

⚙️ Astrocyte Reactivity in 4R-TauopathiesKG

mechanism · 3,071 words · 131 hyp63 ana22 exp

⚙️ Tau Kinase Signaling Cascade in Alzheimer's DiseaseKG

mechanism · 3,059 words · 128 hyp49 ana56 exp

⚙️ Tanycytes: A Novel Tau Clearance Pathway from Brain to BloodKG

mechanism · 3,058 words · 38 hyp50 ana3 exp

🧬 MAPT (Microtubule-Associated Protein Tau) GeneKG

gene · 3,049 words · 53 hyp30 ana20 exp

⚙️ MAPT→Tau→Aggregation→PSP Causal ChainKG

mechanism · 3,015 words · 16 hyp36 ana28 exp

⚙️ Tau Pathology Alters Oligodendrocyte Gene Methylation in [Alzheimer's Disease](/diseases/alzheimers-disease)KG

mechanism · 3,013 words · 67 hyp53 ana48 exp

⚙️ TauopathyKG

mechanism · 3,007 words · 79 hyp52 ana17 exp

🏥 Aging-Related Tau Astrogliopathy (ARTAG)KG

disease · 2,995 words · 17 hyp15 ana6 exp

⚙️ Tau Immunotherapy MechanismsKG

mechanism · 2,983 words · 7 hyp33 ana8 exp

🧪 Tauraso (Nimodipine) ALS TrialKG

clinical · 2,968 words · 183 hyp29 ana30 exp

nct02605785-tau-pet-pspKG

clinical_trial · 2,964 words · 6 hyp5 ana15 exp

📊 Phosphorylated Tau 181 (p-tau 181)KG

biomarker · 2,950 words · 42 hyp22 ana1 exp

⚙️ Tau Proteostasis and Clearance Across 4R-TauopathiesKG

mechanism · 2,932 words · 42 hyp48 ana19 exp

🧪 NIO752 Antisense Oligonucleotide (NCT04539041)KG

clinical · 2,916 words · 17 hyp5 ana16 exp

apn-1607-tau-pet-phase3-nct07422857KG

clinical_trial · 2,900 words · 10 hyp1 ana6 exp

🧪 XTR006 Tau PET for AD (NCT07115238)KG

clinical · 2,889 words · 12 hyp2 ana5 exp

🏛️ TPIRC - Tau Pathology and Immunotherapy Research Center

institution · 2,887 words · 4 hyp8 ana1 exp

⚙️ Cell Death Pathways in 4R-TauopathiesKG

mechanism · 2,854 words · 18 hyp35 ana3 exp

📊 p-Tau Biomarker in Immunoglobulin Light Chain and Transthyretin AmyloidosisKG

biomarker · 2,836 words · 16 hyp5 ana15 exp