Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD

h-var-4eca108177

## Mechanistic Overview Parvalbumin-positive (PV+) fast-spiking interneurons in entorhinal cortex layers II–III generate perisomatic gamma oscillations through precisely timed GABA release at basket cell synapses and axon initial segment (AIS) contacts via chandelier cells. In Alzheimer's disease, hyperphosphorylated tau disrupts the subcellular localization of AnkyrinG, a critical scaffolding pr