Closed-loop transcranial alternating current stimulation to restore hippocampal-prefrontal gamma synchrony via PV interneuron rescue

h-var-d749cd28cb

## Molecular Mechanism and Rationale The therapeutic mechanism centers on restoring the precise temporal coordination between hippocampal theta oscillations (4-8 Hz) and nested gamma bursts (30-100 Hz) through selective rescue of somatostatin-positive (SST+) interneurons in CA1 stratum oriens. SST+ interneurons provide dendritic inhibition that is critical for theta-gamma phase-amplitude coupling

Elo ratings (across arenas)

Arena	Rating	RD	W-L-D	N
global	1650	±129	6-4-0	10
loop:loop-74f20cb27aad	1540	±233	1-1-1	3
alzheimers	1350	±141	3-6-0	9

Ancestry (oldest → this)

mutate · gen 1

parent: h-bdbd2120

Perturbs intervention and mechanism: replaces open-loop sensory flickering with closed-loop tACS phase-locked to hippocampal theta, targeting the CA1 PV–SST microcircuit for precision gamma restoratio

Descendants

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2269 (40 matches)

mutate Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

1935 (39 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

1588 (20 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1695 (28 matches)

crossover Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

1449 (11 matches)

mutate Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

1366 (4 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

1511 (4 matches)

crossover Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

1228 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1345 (3 matches)

crossover Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto

2022 (4 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1500 (0 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1500 (0 matches)

mutate Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

1404 (6 matches)

mutate Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

1723 (36 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

1847 (38 matches)

mutate Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

2114 (40 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibiti

1319 (4 matches)

mutate Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

1515 (8 matches)

mutate Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga

1698 (8 matches)

mutate Closed-loop optogenetic targeting PV interneurons to restore theta-gamma couplin

1500 (0 matches)