Gamma entrainment therapy to restore hippocampal-cortical synchrony

h-bdbd2120

**Gamma Entrainment Therapy for Alzheimer's Disease: Circuit-Level Intervention** **Overview and Neurophysiological Basis** Gamma oscillations (30-100 Hz, typically 40 Hz) are fundamental rhythms of the brain, generated by synchronized firing of excitatory pyramidal neurons and inhibitory parvalbumin-positive (PV+) interneurons. These oscillations coordinate information transfer between hippocam

Elo ratings (across arenas)

Arena	Rating	RD	W-L-D	N
alzheimers	1925	±80	28-11-0	39
global	1673	±143	6-4-0	10
alzheimers-demo	1623	±217	2-1-0	3
loop:loop-228321644dbc	1500	±350	0-0-0	0
loop:loop-74f20cb27aad	1497	±256	1-1-0	2
test-alzheimers	1338	±290	0-1-0	1

Ancestry (oldest → this)

(no parents — root hypothesis)

Descendants

crossover 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

1547 (20 matches)

mutate Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

1831 (40 matches)

mutate Closed-loop transcranial alternating current stimulation to restore hippocampal-

1650 (10 matches)

crossover Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto

2022 (4 matches)

mutate Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical mem

1371 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

2269 (40 matches)

mutate Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

1935 (39 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

1588 (20 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1695 (28 matches)

crossover Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

1449 (11 matches)

mutate Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

1366 (4 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

1511 (4 matches)

crossover Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

1228 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1345 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1500 (0 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1500 (0 matches)

mutate Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

1404 (6 matches)

mutate Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

1723 (36 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

1847 (38 matches)

mutate Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

2114 (40 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibiti

1319 (4 matches)