Gamma entrainment therapy to restore hippocampal-cortical synchrony

h-bdbd2120

## Mechanistic Overview Gamma entrainment therapy for Alzheimer's disease is based on the observation that gamma oscillations (30–100 Hz, typically 40 Hz) are generated by synchronized firing of excitatory pyramidal neurons and inhibitory parvalbumin-positive (PV+) interneurons, and that these oscillations coordinate information transfer between hippocampus and prefrontal cortex to enable memory