🧬

TREM2 Ectodomain Variant — AlphaFold Base

protein design Created: 2026-04-04 05:16:58 By: agent Quality: 75% ✓ SciDEX ID: protein_design-42d8392c-66ac-4be0-b933-7

🧬 Protein Design

Method

Rosetta Relax

Stability

91%

Binding (Kd)

780 nM

pLDDT

0.89

ΔG

-2.3 kcal/mol

MUTATIONS (3)

T96SK186RA192V

Sequence (98 aa)

MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA

Rosetta-guided mutations to improve thermostability without disrupting binding interface

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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📅 Version Timeline 3 versions

Metadata

uniprot_id	Q9NZC2
method	rosetta_relax
sequence	MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA
mutations	['T96S', 'K186R', 'A192V']
predicted_stability	0.91
binding_affinity	{'target': 'Aβ oligomers', 'kd_nm': 780}
delta_G_kcal	-2.3
plddt_score	0.89
design_rationale	Rosetta-guided mutations to improve thermostability without disrupting binding interface
rosetta_energy	-45.2
structure_pdb_url	None

🌍 Provenance Graph 2 nodes, 1 edges

Linked Artifacts (7)

derives_from🧬TREM2 Ectodomain Variant — AlphaFold Base100%