gene

ALZHEIMER DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALZHEIMER DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1790Connections

0Hypotheses

9Analyses

50Outgoing

50Incoming

Summary

ALZHEIMER DISEASE is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with ALS, Aging, Als. Connected to 753 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ALZHEIMER DISEASE
Primary Expression	Ca1, Cortex, Hippocampus
Pathways	Autophagy, Oxidative Stress, Stem Cell, Complement, Immune Response
Associated Diseases	ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Atherosclerosis
Interactions	APP, AUTOPHAGY, TAU, LC3, MTORC1, TFEB
KG Connections	1372 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Ms["Ms"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Cancer["Cancer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Diabetes["Diabetes"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"activates"| Alzheimer_1["Alzheimer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"activates"| Anxiety["Anxiety"]
    TREM2["TREM2"] -->|"associated"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    AKT1["AKT1"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    EGFR["EGFR"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    style ALZHEIMER_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (949)

Target	Relation	Type	Str
Alzheimer	therapeutic_target	disease	1.00
Alzheimer	activates	disease	1.00
Alzheimer	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Aging	associated_with	disease	1.00
Dementia	biomarker_for	disease	1.00
Als	associated_with	disease	1.00
Als	activates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Alzheimer	implicated_in	disease	1.00
Parkinson	associated_with	disease	0.95
Inflammation	associated_with	disease	0.95
Alzheimer	biomarker_for	disease	0.95
Neurodegeneration	therapeutic_target	disease	0.95
Alzheimer	contributes_to	disease	0.95
Neurodegeneration	biomarker_for	disease	0.95
Autophagy	activates	pathway	0.90
ALZHEIMER	activates	gene	0.90
APOE	activates	gene	0.90
ALZHEIMER	associated_with	gene	0.90
DEMENTIA	biomarker_for	gene	0.90
Neurodegeneration	activates	disease	0.85
Dementia	associated_with	disease	0.85
Neuroinflammation	associated_with	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Cancer	associated_with	disease	0.85
Obesity	associated_with	disease	0.85
Alzheimer	causes	disease	0.85
Aging	activates	disease	0.85
Neurodegeneration	inhibits	disease	0.85
Als	biomarker_for	disease	0.85
Aging	biomarker_for	disease	0.85
Oxidative Stress	therapeutic_target	pathway	0.80
DEMENTIA	associated_with	gene	0.80
AMYLOID	associated_with	gene	0.80
Stem Cell	associated_with	pathway	0.80
Alzheimer	interacts_with	disease	0.75
Amyotrophic Lateral Sclerosis	associated_with	disease	0.75
Tauopathy	associated_with	disease	0.75
Inflammation	activates	disease	0.75
Als	interacts_with	disease	0.75
Diabetes	associated_with	disease	0.75
Dementia	interacts_with	disease	0.75
Neurodegeneration	interacts_with	disease	0.75
Alzheimer	expressed_in	disease	0.75
Alzheimer	regulates	disease	0.75
Infection	activates	disease	0.75
Viral Infection	activates	disease	0.75
Neurodegeneration	contributes_to	disease	0.75
Cancer	activates	disease	0.75

Incoming (841)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
ALZHEIMER	therapeutic_target	gene	1.00
TAU	associated_with	gene	1.00
AGING	associated_with	gene	1.00
AMYLOID	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
TAU	implicated_in	entity	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
NEURODEGENERATION	therapeutic_target	gene	0.90
ALZHEIMER'S DISEASE	biomarker_for	gene	0.90
TAU	biomarker_for	gene	0.90
ALZHEIMER	implicated_in	gene	0.90
NEURODEGENERATION	biomarker_for	gene	0.90
NEURODEGENERATION	activates	gene	0.80
NEURODEGENERATIVE DISEASES	associated_with	gene	0.80
AMYLOID	interacts_with	gene	0.80
AMYLOID	biomarker_for	gene	0.80
AMYLOID	associated_with	gene	0.80
ALZHEIMER'S DISEASE	activates	gene	0.80
ALZHEIMER	interacts_with	gene	0.80
TAU	interacts_with	gene	0.80
PARKINSON	associated_with	gene	0.80
ALZHEIMER	causes	gene	0.80
AGING	activates	gene	0.80
ALZHEIMER	contributes_to	gene	0.80
NEURODEGENERATION	inhibits	gene	0.80
APP	activates	gene	0.80
ALZHEIMER	biomarker_for	gene	0.80
TREM2	associated_with	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
MICROGLIA	activates	gene	0.70
ALZHEIMER'S DISEASE	expressed_in	gene	0.70
PER	associated_with	gene	0.70
CANCER	associated_with	gene	0.70
MITOCHONDRIA	interacts_with	gene	0.70
P62	activates	gene	0.70
LC3	activates	gene	0.70
NEURODEGENERATIVE DISORDERS	activates	gene	0.70
TAU	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
GENES	associated_with	gene	0.70
NEURODEGENERATION	interacts_with	gene	0.70
ALZHEIMER	expressed_in	gene	0.70
AUTOPHAGY	therapeutic_target	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
AMYLOID	therapeutic_target	gene	0.70
NEURODEGENERATIVE DISORDERS	implicated_in	gene	0.70
NEURODEGENERATION	contributes_to	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (9)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ALZHEIMER DISEASE

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Pathway Diagram

Outgoing (949)

Incoming (841)

Targeting Hypotheses (0)

Mentioning Analyses (9)

Trans-synaptic tau spreading and propagation mechanisms in AD

Quantitative proteomics of the aging synapse in early Alzheimer disease

Human connectome alterations and network-level dysfunction in Alzheimer disease

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Extracellular vesicle biomarkers for early AD detection

Related Papers (0)

ALZHEIMER DISEASE

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

Therapeutics

Neurons — Cell Type Hierarchy

Pathway Diagram

Outgoing (949)

Incoming (841)

Targeting Hypotheses (0)

Mentioning Analyses (9)

Trans-synaptic tau spreading and propagation mechanisms in AD

Quantitative proteomics of the aging synapse in early Alzheimer disease

Human connectome alterations and network-level dysfunction in Alzheimer disease

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Extracellular vesicle biomarkers for early AD detection

Related Papers (0)