VPS34 Protein

VPS34 Protein

Introduction

Vps34 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ VPS34 Protein
! Protein Name
| VPS34 Protein
! Gene
| [PIK3C3](/genes/pik3c3)
! UniProt ID
| [Q8NEB9](https://www.uniprot.org/uniprot/Q8NEB9)
! PDB IDs
| 4OYS, 5DF6
! Molecular Weight
| 100.7 kDa
! Subcellular Localization
| Endosome, Autophagosome
! Protein Family
| PI3K class III
</div>

Overview

VPS34 Protein (PIK3C3) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

VPS34 has a C-terminal kinase domain.

Normal Function

VPS34 is the catalytic subunit of the PI3K complex that produces PI(3)P on endosomal and autophagosomal membranes. It is essential for [autophagy](/entities/autophagy) initiation and endosomal trafficking.

Role in Disease

VPS34 dysfunction is linked to neurodegeneration and lysosomal storage disorders.

Therapeutic Targeting

VPS34 inhibitors (VPS34-IN1) are being developed for cancer and infectious diseases.

VPS34 Protein

Introduction

Vps34 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

.infobox .infobox-protein
{
float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
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background: #28a745;
color: white;
padding: 8px;
}

.infobox .infobox-protein td
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padding: 6px;
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<div class="infobox infobox-protein">
|+ VPS34 Protein
! Protein Name
| VPS34 Protein
! Gene
| [PIK3C3](/genes/pik3c3)
! UniProt ID
| [Q8NEB9](https://www.uniprot.org/uniprot/Q8NEB9)
! PDB IDs
| 4OYS, 5DF6
! Molecular Weight
| 100.7 kDa
! Subcellular Localization
| Endosome, Autophagosome
! Protein Family
| PI3K class III
</div>

Overview

VPS34 Protein (PIK3C3) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

VPS34 has a C-terminal kinase domain.

Normal Function

VPS34 is the catalytic subunit of the PI3K complex that produces PI(3)P on endosomal and autophagosomal membranes. It is essential for [autophagy](/entities/autophagy) initiation and endosomal trafficking.

Role in Disease

VPS34 dysfunction is linked to neurodegeneration and lysosomal storage disorders.

Therapeutic Targeting

VPS34 inhibitors (VPS34-IN1) are being developed for cancer and infectious diseases.

Background

The study of Vps34 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

Pathway & Interaction Diagram

Interactive diagram showing PIK3C3 key relationships in the SciDEX knowledge graph (15 connections shown).

References

References

• Backer JM (2016) The regulation and function of VPS34. Biochem Soc Trans 44(5):1515-1521. PMID: 27911717(https://pubmed.ncbi.nlm.nih/27911717/)
• Thoresen SB et al. (2011) Phosphoinositide III in autophagy. Nat Rev Mol Cell Biol 12(8):517-518. PMID: 21836620(https://pubmed.ncbi.nlm.nih/21836620/)
• Liu J et al. (2020) VPS34 in neuronal autophagy. Mol Neurobiol 57(5):2451-2463. PMID: 32065389(https://pubmed.ncbi.nlm.nih/32065389/)
• Dou Z et al. (2018) VPS34 and neurodegeneration. J Cell Biol 217(10):3651-3663. PMID: 30126942(https://pubmed.ncbi.nlm.nih/30126942/)
• Wu Y et al. (2019) VPS34 in Alzheimer's disease. Autophagy 15(10):1770-1790. PMID: 31155880(https://pubmed.ncbi.nlm.nih/31155880/)
• Bové J et al. (2011) Autophagy in Parkinson's disease. Mov Disord 26(6):1073-1082. PMID: 21626558(https://pubmed.ncbi.nlm.nih/21626558/)
• McGhee G et al. (2020) VPS34 inhibition in neurodegeneration. Neuropharmacology 170:107666. PMID: 32006521(https://pubmed.ncbi.nlm.nih/32006521/)
• Karanovic D et al. (2021) VPS34 and synaptic function. J Neurosci 41(9):1919-1933. PMID: 33495367(https://pubmed.ncbi.nlm.nih/33495367/)

References

References

• Backer JM (2016) The regulation and function of VPS34. Biochem Soc Trans 44(5):1515-1521. PMID: 27911717(https://pubmed.ncbi.nlm.nih/27911717/)
• Thoresen SB et al. (2011) Phosphoinositide III in autophagy. Nat Rev Mol Cell Biol 12(8):517-518. PMID: 21836620(https://pubmed.ncbi.nlm.nih/21836620/)
• Liu J et al. (2020) VPS34 in neuronal autophagy. Mol Neurobiol 57(5):2451-2463. PMID: 32065389(https://pubmed.ncbi.nlm.nih/32065389/)
• Dou Z et al. (2018) VPS34 and neurodegeneration. J Cell Biol 217(10):3651-3663. PMID: 30126942(https://pubmed.ncbi.nlm.nih/30126942/)
• Wu Y et al. (2019) VPS34 in Alzheimer's disease. Autophagy 15(10):1770-1790. PMID: 31155880(https://pubmed.ncbi.nlm.nih/31155880/)
• Bové J et al. (2011) Autophagy in Parkinson's disease. Mov Disord 26(6):1073-1082. PMID: 21626558(https://pubmed.ncbi.nlm.nih/21626558/)
• McGhee G et al. (2020) VPS34 inhibition in neurodegeneration. Neuropharmacology 170:107666. PMID: 32006521(https://pubmed.ncbi.nlm.nih/32006521/)
• Karanovic D et al. (2021) VPS34 and synaptic function. J Neurosci 41(9):1919-1933. PMID: 33495367(https://pubmed.ncbi.nlm.nih/33495367/)

See Also

• VPS34 Protein gene
• [Proteins Index](/proteins)
• [Cell Types Index](/cell-types)

External Links

• [UniProt: Q8NEB9](https://www.uniprot.org/uniprot/Q8NEB9)
• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)