Serine/Arginine-Rich Protein Kinase Modulation

**Molecular Mechanism and Rationale** The serine/arginine-rich protein kinases SRPK1 and CLK1 represent critical regulatory nodes in the post-transcriptional control of RNA metabolism, particularly in the phosphorylation of splicing regulators that govern TDP-43 functionality. TDP-43 (TAR DNA-binding protein 43) is a predominantly nuclear RNA-binding protein that becomes pathologically cytoplasmic and aggregated in numerous neurodegenerative diseases, including amyotrophic lateral sclerosis (AL...