Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial delivery

**Molecular Mechanism and Rationale** The therapeutic hypothesis centers on engineering chimeric proteins that combine the mitochondrial cargo-binding specificity of TRAK1 (Trafficking Kinesin Protein 1) with enhanced kinesin heavy chain motor domains, specifically modified KIF5A variants. TRAK1 functions as a critical adaptor protein that links mitochondria to the kinesin-1 motor complex through direct interactions with the mitochondrial outer membrane protein Miro1/2 (mitochondrial Rho GTPase...