APOE-Mediated Synaptic Lipid Raft Stabilization

**Background and Rationale** Apolipoprotein E (APOE) genotype represents the strongest genetic risk factor for late-onset Alzheimer's disease, with the APOE4 allele conferring a 3-15 fold increased risk compared to the more common APOE3 variant. While extensive research has focused on APOE's role in amyloid-β clearance and tau pathology, emerging evidence suggests that APOE4's pathogenic effects extend to fundamental alterations in synaptic membrane composition and function. Lipid rafts, specia...