## Mechanistic Overview
Epigenetic Silencing of Tumor Suppressor Genes in Cancer Progression rests on the following mechanistic claim: This hypothesis proposes that hypermethylation of CpG islands in the promoter region of the TP53 tumor suppressor gene leads to transcriptional silencing and subsequent loss of p53 function in colorectal cancer development. The p53 protein normally acts as a critical checkpoint regulator in the cell cycle, inducing apoptosis or cell cycle arrest in response to DN
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.81
Evidence
0.30
Novelty
0.50
Feasibility
0.40
Impact
0.41
Druggability
0.35
Safety
0.53
Competition
0.45
Data
0.10
Reproducible
0.60
Score Breakdown
Dimension
Epigenetic Silencing of Tumor
Mechanistic
0.810
Evidence
0.300
Novelty
0.500
Feasibility
0.400
Impact
0.410
Druggability
0.350
Safety
0.530
Competition
0.450
Data
0.100
Reproducible
0.600
Evidence
Epigenetic Silencing of Tumor Suppressor Genes in Cancer Pro
No evidence citations yet
Price History Overlay
Pathway Diagrams
Curated mechanism pathway diagrams from expert analysis