Versioned tabular datasets with provenance tracking and citation indexing
Answer-key dataset for the Forge benchmark bench_glymphatic_clearance_biomarker_panel_v1 (Glymphatic Clearance Biomarker Panel). The table contains 18 curated ground-truth rows exported from the bench
Answer-key dataset for the Forge benchmark bench_neurodegeneration_drug_target_druggability_v1 (Neurodegeneration Drug Target Druggability). The table contains 29 curated ground-truth rows exported fr
Answer-key dataset for the Forge benchmark bench_als_motor_neuron_survival_genes_v1 (ALS Motor Neuron Survival Gene Prediction). The table contains 22 curated ground-truth rows exported from the bench
Answer-key dataset for the Forge benchmark bench_pd_dopaminergic_expression_signature_v1 (PD Dopaminergic Neuron Expression Signature). The table contains 20 curated ground-truth rows exported from th
Answer-key dataset for the Forge benchmark bench_ad_protein_aggregation_propensity_v1 (AD Protein Aggregation Propensity). The table contains 24 curated ground-truth rows exported from the benchmark e
Single-cell RNA-seq atlas profiling p16/p21-positive senescent cells in aging human brain, including senescent astrocytes, microglia, and oligodendrocyte precursors. Includes data from Musi et al. 201
Aggregated polysomnography (PSG) and sleep EEG studies examining sleep disruption as biomarker and driver of neurodegeneration, including the Wisconsin Sleep Cohort, the SHHS (Sleep Heart Health Study
Curated collection of 16S rRNA amplicon sequencing studies comparing gut microbiome composition in Parkinson's disease patients vs. controls, including the landmark Sampson et al. 2016 Cell study (GEO
NIAGADS (NIA Genetics of Alzheimer's Disease Data Storage Site) hosts GWAS summary statistics, whole-genome sequencing, and genotype data from major AD studies including ADGC, IGAP, and follow-up coho
Open-access neural dynamics recordings from Allen Institute. Includes electrophysiology datasets spanning hippocampal circuits, cortical dynamics, and sensory processing in mouse models. Provides circ
ENCODE Project data for neuronal and brain cell types including H3K27ac, H3K4me3, H3K27me3 ChIP-seq and ATAC-seq profiling of neurons, astrocytes, and microglia. Provides reference chromatin state map
Reference neuropathological staging data for tau (Braak 0-VI) and alpha-synuclein (Braak PD stages 1-6) pathology progression, derived from the original Braak et al. studies (2003 Neurobiology of Agin
Multi-study atlas of gene expression changes in the aging mouse brain, spanning 3 to 24 months of age across multiple brain regions. Combines bulk RNA-seq from the Tabula Muris Senis (Allen Institute
The Human Connectome Project (HCP) provides high-resolution structural and functional MRI data from 1,200+ healthy young adults plus the Lifespan HCP for aging cohorts. Provides normative connectome d
Cryo-EM structural data of tau filament polymorphs from human brain tissue, including AD paired helical filaments (PHF), PSP 4R-tau strains, CBD 4R-tau strains (astrocytic plaques), and CTE strains. F
MRI-derived measurements of perivascular space (PVS) volume, glymphatic clearance function (DTI-ALPS index), and cerebrospinal fluid dynamics in AD cohorts. Includes data from the ADNI PVS substudy, t
Lipidomics datasets profiling cholesterol, sphingolipid, and phospholipid composition of synaptic membranes and lipid rafts in aging and AD brains. Includes data from Fabelo et al. 2014 Frontiers in P
Aggregated wearable sensor, smartphone, and clinical digital biomarker datasets for neurodegeneration prediction, including the UPDRS/MDS-UPDRS sensor substudy, the FDA MyStudies digital PD data, and
The Parkinson's Progression Markers Initiative (PPMI) is a landmark observational study of 400+ newly diagnosed PD patients followed longitudinally with clinical, imaging, and biomarker data. CSF alph
Genome-wide CRISPR screen datasets in neuronal cell lines and iPSC-derived neurons identifying genes modifying neurodegeneration. Includes Hart et al. 2015 Science (essential gene screen), Tian et al.
Proteomic characterization of blood-brain barrier surface receptors including transferrin receptor (TfR1), LRP1, TMEM30A, and related antibody transcytosis targets. Aggregated from BBB proteomics stud
The Accelerating Medicines Partnership for AD (AMP-AD) Knowledge Portal on Synapse hosts multi-omics datasets from ROSMAP, MSBB, and Mayo Clinic cohorts including bulk RNA-seq, snRNA-seq, proteomics,
UK Biobank Alzheimer's disease by proxy GWAS (Marioni et al. 2018; PMID 30315176). IEU OpenGWAS accession ieu-b-2. Phenotype: one or both parents with self-reported AD (UKB Fields 20107/20110). N=314,
Registered via Biomni parity pipeline. URL: https://www.niagads.org/node/42221 | Version: 2024-06 | Institution: NIAGADS
Registered via Biomni parity pipeline. URL: https://github.com/sqjin/CellChat | Version: 2024-06 | Institution: CUHK
Structured registry of Alzheimer's Disease clinical trials with NCT identifiers, source URLs, update timestamps, phase, status, mechanism, intervention, enrollment, and evidence tiers. Covers active r
Registered via Biomni parity pipeline. URL: https://clinicaltrials.gov/api/query/study_fields | Version: 2026-04 | Institution: NIH/NLM
Wisconsin Registry for Alzheimer's Prevention (WRAP) — longitudinal AD-risk cohort with cognitive assessments, A/T/N CSF biomarkers (Aβ42/40, p-tau181, t-tau, NfL, neurogranin), neuroimaging (AV45/PiB
Registered via Biomni parity pipeline. URL: http://adni.loni.usc.edu/data-samples/adni-data/ | Version: 2024-12 | Institution: UCSF/Loni UCLA
Registered via Biomni parity pipeline. URL: https://naccdata.org/data-access/uniform-data-set | Version: 2024-06 | Institution: NACC/UW
Registered via Biomni parity pipeline. URL: http://adni.loni.usc.edu/data-samples/adni-data/ | Version: 2024-12 | Institution: UCSF/Loni UCLA
Registered via Biomni parity pipeline. URL: https://platform.opentargets.org/disease/MONDO_0004975/associations | Version: 2026-04 | Institution: OpenTargets
Registered via Biomni parity pipeline. URL: https://www.ebi.ac.uk/gwas/efotraits/EFO_0000249 | Version: 2026-04 | Institution: NHGRI-EBI
Registered via Biomni parity pipeline. URL: https://www.synapse.org/#!Synapse:syn3606086 | Version: 2024-06 | Institution: Rush University
Registered via Biomni parity pipeline. URL: https://www.synapse.org/#!Synapse:syn21587433 | Version: 2024-03 | Institution: Banner/Army MRT
Registered via Biomni parity pipeline. URL: https://www.synapse.org/#!Synapse:syn3157744 | Version: 2024-03 | Institution: Mayo Clinic
Registered via Biomni parity pipeline. URL: https://www.synapse.org/#!Synapse:syn3157743 | Version: 2024-03 | Institution: Mount Sinai
Registered via Biomni parity pipeline. URL: https://cellxgene.cziscience.com/ | Version: 2025-01 | Institution: CZIS
Registered via Biomni parity pipeline. URL: https://knowledge.brain-map.org/spatialdata | Version: 2025-01 | Institution: Allen Institute
Registered via Biomni parity pipeline. URL: https://cellxgene.cziscience.com/collections/1ca90a40-d852-4f62-8ed2-68886a6a33d4 | Version: 2024-12 | Institution: University of Washington
Registered via Biomni parity pipeline. URL: https://www.ncbi.nlm.nih.gov/gene/4137 | Version: 2024-06 | Institution: NCBI
Registered via Biomni parity pipeline. URL: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186868 | Version: 112 | Institution: EBI/Sanger
Registered via Biomni parity pipeline. URL: https://gmrepo.humangut.info/ | Version: 2024-01 | Institution: HKUST
Registered via Biomni parity pipeline. URL: https://www.ebi.ac.uk/ena/browser/view/PRJNA385613 | Version: 2024-06 | Institution: Various
Registered via Biomni parity pipeline. URL: https://www.synapse.org/#!Synapse:syn3388564 | Version: 2024-06 | Institution: Rush University
Registered via Biomni parity pipeline. URL: https://cellxgene.cziscience.com/collections/1ca90a40-d852-4f62-8ed2-68886a6a33d4 | Version: 2024-12 | Institution: University of Washington
Registered via Biomni parity pipeline. URL: https://www.rcsb.org/structure/6CU7 | Version: 2024-06 | Institution: RCSB
Registered via Biomni parity pipeline. URL: https://alphafold.ebi.ac.uk/entry/P37840 | Version: 2024-01 | Institution: DeepMind/EMBL-EBI
Registered via Biomni parity pipeline. URL: https://ftp.ncbi.nlm.nih.gov/1000genomes/ftp/release/20130502/ | Version: Phase 3 | Institution: NCBI/IGSR
Registered via Biomni parity pipeline. URL: https://www.niagads.org/node/42221 | Version: 2024-06 | Institution: NIAGADS
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Registry of AD drug targets, approved and failed, with mechanism, status, and evidence quality.
Curated cell-type marker genes for microglia, astrocytes, neurons, and oligodendrocytes in AD research.
Ground-truth answer key for the OT-AD Target Ranking benchmark (bench_ot_ad_target_ranking_v1). Each row is a gene symbol; is_top10pct indicates whether the gene falls in the top 10% of Open Targets P
Registry of CSF, plasma, and imaging biomarkers used for AD diagnosis, staging, and monitoring. Initial v1 set covers the established A/T/N framework biomarkers (amyloid, tau, neurodegeneration) plus
Curated registry of Phase 3 AD clinical trials with their outcomes, mechanism, and (for failures) the most likely contributing factors. Initial v1 set focuses on landmark anti-amyloid and secretase tr
Curated registry of genetic loci associated with Alzheimer's disease risk, including landmark common variants identified by GWAS and the autosomal-dominant familial AD genes (APP, PSEN1, PSEN2). Effec