Market Dynamics

Real-time price movements driven by evidence, debates, and score changes

526
Hypotheses
$0.50
Avg Price
44,233
Total Events
↗ 6
Rising
↘ 15
Falling
↔ 427
Stable
45
Health (Moderate)
📈 Aggregate Market (14 days) 0.420.470.520.580.63 04-0204-0604-1104-15 $0.521 $0.470 ▼ 9.9% Market Avg Price (14d)

🚀 24h Price Velocity

Hypotheses moving fastest in the last 24 hours — cents per hour of price change

SYK-Independent TREM2 Pathways Remain Functional i
▲ +0.025 25.2¢/hr 3 events
$0.55 → $0.58 ▲4.6%
H7: Enteric Nervous System Alpha-Synuclein Propaga
▲ +0.022 22.3¢/hr 3 events
$0.59 → $0.61 ▲3.8%
TREM2 R47H Metabolic Lock-in at Cholesterol Ester
▲ +0.014 14.1¢/hr 3 events
$0.56 → $0.57 ▲2.5%
PGC1α Activation in PV+ Interneurons Bypasses Mito
▲ +0.008 8.1¢/hr 3 events
$0.45 → $0.46 ▲1.8%
DLK MAPK Pathway Inhibition to Block Tau-Induced N
▲ +0.006 6.1¢/hr 3 events
$0.61 → $0.62 ▲1.0%
ER Stress Reduction as Adjunctive Therapy to Suppo
▼ -0.005 4.8¢/hr 3 events
$0.57 → $0.57 ▼0.8%
GPC4/HSPGs Collaborate with ApoE Isoforms to Dicta
▲ +0.005 4.8¢/hr 3 events
$0.58 → $0.58 ▲0.8%
TREM2-Mediated Cholesterol Dysregulation in Microg
▼ -0.040 3.9¢/hr 2 events
$0.54 → $0.50 ▼16.5%

📈 Top Movers

Hypotheses with the largest price movements, ranked by absolute change

TREM2-Dependent Microglial Senescence Transition
▲ 164.4% $0.80 Gap: 0.11
▲164.4%
148 events · Score: 0.692
APOE-Dependent Autophagy Restoration
▲ 114.6% $0.66 Gap: 0.04
▲114.6%
158 events · Score: 0.615
ACSL4-Driven Ferroptotic Priming in Disease-Associated
▲ 103.1% $0.62 Gap: 0.01
▲118.8%
203 events · Score: 0.662
APOE4-Specific Lipidation Enhancement Therapy
▲ 56.4% $0.84 Gap: 0.01
▲56.4%
112 events · Score: 0.845
Selective TLR4 Modulation to Prevent Gut-Derived Neuroi
▲ 91.9% $0.59 Gap: 0.03
▲91.9%
175 events · Score: 0.617
Microglial-Mediated Tau Clearance Dysfunction via TREM2
▲ 51.6% $0.71 Gap: 0.18
▲51.6%
71 events · Score: 0.533
Gamma entrainment therapy to restore hippocampal-cortic
▲ 47.9% $0.74 Gap: 0.12
▲59.5%
179 events · Score: 0.681
Cryptic Exon Silencing Restoration
▼ 32.7% $0.47 Gap: 0.01
▼32.7%
166 events · Score: 0.462
Targeted Butyrate Supplementation for Microglial Phenot
▲ 74.3% $0.53 Gap: 0.03
▲74.3%
133 events · Score: 0.559
Membrane Cholesterol Gradient Modulators
▼ 32.2% $0.46 Gap: 0.06
▼32.2%
164 events · Score: 0.517
Enhancing Vagal Cholinergic Signaling to Restore Gut-Br
▲ 71.1% $0.52 Gap: 0.01
▲71.1%
96 events · Score: 0.512
Selective HDAC3 Inhibition with Cognitive Enhancement
▼ 27.8% $0.54 Gap: 0.02
▼27.8%
156 events · Score: 0.563

⚡ Recent Price Events

Evidence, debate, and scoring events that triggered price adjustments (last 48h)

TimeEventHypothesisPrice / ΔScoreSource
04-16T03:56 📄 New Evidence GPC4/HSPGs Collaborate with ApoE Isoforms to Dicta $0.58▼-0.056 0.583 evidence_update
04-16T03:56 📄 New Evidence GPC4/HSPGs Collaborate with ApoE Isoforms to Dicta $0.64▲+0.061 0.583 evidence_update
04-16T03:56 Listed GPC4/HSPGs Collaborate with ApoE Isoforms to Dicta $0.58 0.583 post_process
04-15T22:55 📄 New Evidence TREM2 R47H Metabolic Lock-in at Cholesterol Ester $0.57▼-0.048 0.563 evidence_update
04-15T22:55 📄 New Evidence TREM2 R47H Metabolic Lock-in at Cholesterol Ester $0.62▲+0.062 0.563 evidence_update
04-15T22:55 Listed TREM2 R47H Metabolic Lock-in at Cholesterol Ester $0.56 0.563 post_process
04-15T20:24 📄 New Evidence Integrated Biomarker Panel for Therapeutic Window $0.61▼-0.056 0.615 evidence_update
04-15T20:24 📄 New Evidence Integrated Biomarker Panel for Therapeutic Window $0.67▲+0.056 0.615 evidence_update
04-15T20:24 Listed Integrated Biomarker Panel for Therapeutic Window $0.61 0.615 post_process
04-15T19:34 📄 New Evidence DLK MAPK Pathway Inhibition to Block Tau-Induced N $0.62▼-0.054 0.609 evidence_update
04-15T19:34 📄 New Evidence DLK MAPK Pathway Inhibition to Block Tau-Induced N $0.67▲+0.060 0.609 evidence_update
04-15T19:34 Listed DLK MAPK Pathway Inhibition to Block Tau-Induced N $0.61 0.609 post_process
04-15T19:08 📄 New Evidence H7: Enteric Nervous System Alpha-Synuclein Propaga $0.61▼-0.045 0.595 evidence_update
04-15T19:08 📄 New Evidence H7: Enteric Nervous System Alpha-Synuclein Propaga $0.66▲+0.067 0.595 evidence_update
04-15T19:08 Listed H7: Enteric Nervous System Alpha-Synuclein Propaga $0.59 0.595 post_process
04-15T17:28 📄 New Evidence ER Stress Reduction as Adjunctive Therapy to Suppo $0.57▼-0.061 0.566 evidence_update
04-15T17:28 📄 New Evidence ER Stress Reduction as Adjunctive Therapy to Suppo $0.63▲+0.056 0.566 evidence_update
04-15T17:28 Listed ER Stress Reduction as Adjunctive Therapy to Suppo $0.57 0.566 post_process
04-15T13:45 📄 New Evidence PGC1α Activation in PV+ Interneurons Bypasses Mito $0.46▼-0.051 0.455 evidence_update
04-15T13:45 📄 New Evidence PGC1α Activation in PV+ Interneurons Bypasses Mito $0.51▲+0.059 0.455 evidence_update
04-15T13:45 Listed PGC1α Activation in PV+ Interneurons Bypasses Mito $0.45 0.455 post_process
04-15T11:25 📄 New Evidence Timed Senolytic Therapy Eliminates p16^Ink4a/p21^C $0.59▼-0.058 0.587 evidence_update
04-15T11:25 📄 New Evidence Timed Senolytic Therapy Eliminates p16^Ink4a/p21^C $0.65▲+0.058 0.587 evidence_update
04-15T11:25 Listed Timed Senolytic Therapy Eliminates p16^Ink4a/p21^C $0.59 0.587 post_process
04-15T05:50 📄 New Evidence SYK-Independent TREM2 Pathways Remain Functional i $0.58▼-0.040 0.555 evidence_update
04-15T05:50 📄 New Evidence SYK-Independent TREM2 Pathways Remain Functional i $0.62▲+0.065 0.555 evidence_update
04-15T05:50 Listed SYK-Independent TREM2 Pathways Remain Functional i $0.55 0.555 post_process
04-14T20:07 📄 New Evidence M1 Muscarinic Receptor Agonism as Pharmacological $0.60▼-0.054 0.589 evidence_update
04-14T20:07 📄 New Evidence M1 Muscarinic Receptor Agonism as Pharmacological $0.65▲+0.060 0.589 evidence_update
04-14T20:07 Listed M1 Muscarinic Receptor Agonism as Pharmacological $0.59 0.589 post_process
04-14T14:57 📄 New Evidence C3aR Blockade Disrupts the Microglial-Astrocyte Fe $0.60▼-0.057 0.596 evidence_update
04-14T14:57 📄 New Evidence C3aR Blockade Disrupts the Microglial-Astrocyte Fe $0.66▲+0.061 0.596 evidence_update
04-14T14:57 Listed C3aR Blockade Disrupts the Microglial-Astrocyte Fe $0.60 0.596 post_process
04-14T14:03 📄 New Evidence STMN2 Restoration as a Prerequisite for Axon Growt $0.67▼-0.054 0.658 evidence_update
04-14T14:03 📄 New Evidence STMN2 Restoration as a Prerequisite for Axon Growt $0.72▲+0.060 0.658 evidence_update
04-14T14:03 Listed STMN2 Restoration as a Prerequisite for Axon Growt $0.66 0.658 post_process
04-14T11:28 📄 New Evidence CSF Biomarker-Guided ABCA7 Therapeutic Dosing $0.65▼-0.038 0.619 evidence_update
04-14T11:28 📄 New Evidence CSF Biomarker-Guided ABCA7 Therapeutic Dosing $0.69▲+0.068 0.619 evidence_update
04-14T11:28 Listed CSF Biomarker-Guided ABCA7 Therapeutic Dosing $0.62 0.619 post_process
04-14T10:34 📄 New Evidence GAS6/TAM Axis Activation Stabilizes Blood-Brain Ba $0.51▼-0.054 0.498 evidence_update
04-14T10:34 📄 New Evidence GAS6/TAM Axis Activation Stabilizes Blood-Brain Ba $0.56▲+0.060 0.498 evidence_update
04-14T10:34 Listed GAS6/TAM Axis Activation Stabilizes Blood-Brain Ba $0.50 0.498 post_process

📄 Evidence Impact Analysis

How new evidence citations drive hypothesis price movements — before and after comparison

Evidence Impact
+0.003
Avg Impact
20
Price Up
20
Price Down
40
Events
Evidence
+0.003
Debate
+0.017
Recent Evidence Price Changes
▼8.7%
$0.64 → $0.58
▲0.8%
▲10.5%
$0.58 → $0.64
▲0.8%
▼7.7%
$0.62 → $0.57
▲2.5%
▲11.1%
$0.56 → $0.62
▲2.5%
▼8.4%
$0.67 → $0.61
▲9.2%
$0.61 → $0.67
▼8.0%
$0.67 → $0.62
▲1.0%
▲9.8%
$0.61 → $0.67
▲1.0%

⚖ Price-Score Convergence

Hypotheses where market price diverges most from composite score — potential mispricing signals

HypothesisScorePriceGapHistory
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -
[Archived Hypothesis] 0.000 $0.50 Underpriced (0.000) -

Event Breakdown

refresh
19929
snapshot
9607
recalibration
3625
ci_snapshot
2205
evidence
1974
elo_signal
1147
paper_signal
600
score_update
558
debate
479
reproducibility_signal
396
competitive_landscape_signal
349
kg_connectivity_signal
343
periodic_snapshot
341
trajectory_signal
336
debate_signal
327
epistemic_status_signal
296
artifact_support_signal
264
evidence_validation_signal
251
created
222
convergence_signal
207
clinical_relevance_signal
198
participant_signal
173
testability_signal
158
elo_surprise
131
dimension_coherence
46
duplicate_signal
31
staleness_decay
28
gate_flags_signal
10
market_seed
1
experiment_result
1

How Market Prices Work

Evidence events — When new PubMed papers are linked, prices adjust ~8% per citation via logarithmic impact.

Debate rounds — AI personas (Theorist, Skeptic, Expert, Synthesizer) score hypotheses; quality-weighted price shifts with volatility decay.

Score updates — 10-dimensional composite scores (mechanistic plausibility, novelty, feasibility, etc.) drive 70% of price; 30% is momentum.

LMSR pricing — Bounded tanh-based model prevents wild swings while remaining responsive to new information.