ATG4D

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG4D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for ATG4D Gene

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graph TD
    ATG4D["ATG4D (Autophagy Related 4D Cysteine Peptidase)"]
    LC3["LC3 (Microtubule Associated Protein 1 Light Chain 3)"]
    GABARAP["GABARAP (Gamma-Aminobutyric Acid Receptor Associated Protein)"]
    PE["Phosphatidylethanolamine (PE)"]
    AUTOPHAGOSOME["Autophagosome Formation"]
    PROTEIN_AGG["Protein Aggregates"]
    ALPHA_SYN["alpha-Synuclein Aggregates"]
    TAU_AGG["Tau Protein Aggregates"]
    AMYLOID["Amyloid-beta Aggregates"]
    MITOPHAGY["Mitophagy"]
    DAMAGED_MITO["Damaged Mitochondria"]
    NEURONAL_DEATH["Neuronal Cell Death"]
    PARKINSONS["Parkinson's Disease"]
    ALZHEIMERS["Alzheimer's Disease"]
    HUNTINGTONS["Huntington's Disease"]
    NEURODEGENERATION["Neurodegeneration"]

    ATG4D -->|"cleaves"| LC3
    ATG4D -->|"cleaves"| GABARAP
    LC3 -->|"conjugates to"| PE
    GABARAP -->|"conjugates to"| PE
    LC3 -->|"promotes"| AUTOPHAGOSOME
    GABARAP -->|"promotes"| AUTOPHAGOSOME
    AUTOPHAGOSOME -->|"degrades"| PROTEIN_AGG
    AUTOPHAGOSOME -->|"removes"| DAMAGED_MITO
    DAMAGED_MITO -->|"via mitophagy"| MITOPHAGY
    PROTEIN_AGG -->|"includes"| ALPHA_SYN
    PROTEIN_AGG -->|"includes"| TAU_AGG
    PROTEIN_AGG -->|"includes"| AMYLOID
    ALPHA_SYN -->|"contributes to"| PARKINSONS
    TAU_AGG -->|"contributes to"| ALZHEIMERS
    AMYLOID -->|"contributes to"| ALZHEIMERS
    PARKINSONS -->|"leads to"| NEURODEGENERATION
    ALZHEIMERS -->|"leads to"| NEURODEGENERATION
    HUNTINGTONS -->|"leads to"| NEURODEGENERATION
    NEURONAL_DEATH -->|"causes"| NEURODEGENERATION

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class ATG4D central
    class LC3,GABARAP,AUTOPHAGOSOME,MITOPHAGY protective
    class PROTEIN_AGG,ALPHA_SYN,TAU_AGG,AMYLOID,DAMAGED_MITO,NEURONAL_DEATH pathological
    class PE regulatory
    class PARKINSONS,ALZHEIMERS,HUNTINGTONS,NEURODEGENERATION disease