gene

ATG4B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

197Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ATG4B
Full Name	Autophagy Related 4B Cysteine Peptidase
Chromosome	2q37.3
Protein Type	Protease
Function	encodes a cysteine protease that plays a fundamental role in the autophagy pathway, the cell's primary degradation system for clearing damaged proteins, aggregates, and organelles.
Amino Acids	393 aa
Gene Type	Protein-coding
UniProt ID	Q9Y4P1
NCBI Gene ID	23192
Ensembl ID	ENSG00000135679
OMIM	604353
GeneCards	ATG4B
Human Protein Atlas	ATG4B
Protein Size	393 amino acids
Associated Diseases	Als
Known Drugs/Compounds	K33-Branched Ubiquitin Chains
Interactions	LC3, NCOA4, RAB7A, CAT, BRCA1, TDP-43
KG Connections	197 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG4B["ATG4B (Autophagy Related 4B Cysteine Peptidase)"]
    TDP43["TDP-43 Protein"]
    LC3["LC3 Processing"]
    LC3_II["LC3-II Formation"]
    Autophagy["Autophagy Pathway"]
    Macroautophagy["Macroautophagy"]
    Ferroptosis["Ferroptosis"]
    LCN2["Lipocalin-2 (LCN2)"]
    ALS["Amyotrophic Lateral Sclerosis"]
    Macular_Degeneration["Macular Degeneration"]
    Cancer["Cancer"]
    ATG3["ATG3"]
    TARDBP["TARDBP Gene"]
    Cryptic_Splicing["Cryptic Splicing"]
    
    TDP43 -->|"inhibits"| ATG4B
    ATG4B -->|"activates"| Autophagy
    ATG4B -->|"regulates"| Macroautophagy
    ATG4B -->|"processes"| LC3
    ATG4B -->|"regulates"| LC3_II
    LC3 -->|"promotes"| Autophagy
    ATG4B -->|"contributes to"| Ferroptosis
    Ferroptosis -->|"feedback activates"| ATG4B
    LCN2 -->|"interacts with"| ATG4B
    ATG4B -->|"involved in"| Cryptic_Splicing
    ATG4B -->|"therapeutic target"| ALS
    ATG4B -->|"associated with"| Macular_Degeneration
    ATG4B -->|"therapeutic target"| Cancer
    ATG4B -->|"targets"| ATG3
    ATG4B -->|"targets"| TARDBP
    
    style ATG4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style Autophagy fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style Macroautophagy fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style LC3 fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style Ferroptosis fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style ALS fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Cancer fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Macular_Degeneration fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style TDP43 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style TARDBP fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px

Outgoing (129)

Target	Relation	Type	Str
Autophagy	regulates	process	0.98
MAP1LC3	substrate_of	protein	0.92
neural tissue	expressed_in	cell_type	0.90
LC3-II	binds	protein	0.87
LC3ylation	involved_in	process	0.85
Lc3Ylation	involved_in	process	0.85
LC3YLATION	mediates	biological_process	0.85
Ferroptosis	contributes_to	process	0.85
Autophagy	involved_in	process	0.85
Cryptic Splicing	involved_in	process	0.80
autophagy pathway	participates_in	pathway	0.80
macroautophagy	regulates	process	0.70
Ferroptosis	activates	pathway	0.70
Autophagy	activates	pathway	0.70
FERROPTOSIS	activates	gene	0.70
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Cancer	activates	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Macular Degeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Pain	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Als	inhibits	disease	0.65
Als	degrades	disease	0.65
LC3_II	regulates	protein	0.64
FERROPTOSIS	contributes_to	phenotype	0.64
TARDBP	therapeutic_target	gene	0.60
ATG3	therapeutic_target	gene	0.60
ATG3	contributes_to	gene	0.60
LC3	interacts_with	gene	0.60
CAT	therapeutic_target	gene	0.60
NCOA4	activates	gene	0.60
RAB7A	activates	gene	0.60
BECN1	contributes_to	gene	0.60
CAT	inhibits	gene	0.60
ATG5	contributes_to	gene	0.60
ATG7	contributes_to	gene	0.60
ATG3	regulates	gene	0.60
TARDBP	associated_with	gene	0.60
CAT	regulates	gene	0.60
ATG13	contributes_to	gene	0.60
LC3	regulates	entity	0.60
BRCA1	activates	gene	0.60
TDP-43	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60

Incoming (68)

Source	Relation	Type	Str
TARDBP	regulates	gene	0.95
UBE3C	interacts_with	gene	0.95
K33-Branched Ubiquitin Chains	modulates	compound	0.93
TDP-43	inhibits	protein	0.90
TDP43	inhibits	entity	0.90
TARDBP	inhibits	protein	0.90
LCN2	binds	protein	0.90
UBE3C	phosphorylates	protein	0.90
UBE3C	ubiquitinates	gene	0.90
TDP-43	regulates	protein	0.80
cryptic splicing	associated_with	process	0.80
LCN2	interacts_with	protein	0.72
FERROPTOSIS	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
CAT	therapeutic_target	gene	0.60
ATG13	contributes_to	gene	0.60
ATG5	contributes_to	gene	0.60
BECN1	contributes_to	gene	0.60
NCOA4	activates	gene	0.60
ATG7	contributes_to	gene	0.60
RAB7A	activates	gene	0.60
ATG3	therapeutic_target	gene	0.60
ATG3	contributes_to	gene	0.60
ATG3	inhibits	gene	0.60
LC3	interacts_with	gene	0.60
TARDBP	associated_with	gene	0.60
LC3	therapeutic_target	gene	0.60
ATG3	activates	gene	0.60
ATG7	activates	gene	0.60
NBR1	activates	gene	0.60
P62	activates	gene	0.60
TARDBP	therapeutic_target	gene	0.60
ATG3	regulates	gene	0.60
CAT	regulates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
LC3	inhibits	gene	0.60
ATG4D	associated_with	gene	0.60
ATG4A	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURON	regulates	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
LIPOPHAGY	activates	gene	0.60
CANCER	activates	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG4B

Understanding Entity Pages

Wiki Pages (21)

ATG4B — Autophagy Related 4B Cysteine Peptidase

MAP1LC3A Gene

Serum Amino Acid Biomarkers for Brain Hypometabolism

Autophagy Enhancers for PD

ATG4D Gene

Autophagy Molecular Regulation in Neurodegeneration

ATG4C Gene

mHTT Clearance Mechanisms in Huntington's Disease

ATG5 — Autophagy Related 5

ATG3 Gene

Macroautophagy Dysfunction Validation Framework in Parkinson's Disease

ATG4B Protein — Autophagy Related 4B

STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease

ATG4A Protein

ATG12 Protein (Autophagy-related Protein 12)

MAP1LC3A Gene

MAP1LC3B2 Protein

ATG4A Gene

ATG1

ATG4C Protein