Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about atg4a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATG4A |
| Chromosome | Xq22.1 |
| Protein Type | Protease |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues with high expression in: |
| Molecular Weight | 44 kDa |
| Amino Acids | 393 aa |
| Exons | 14 |
| Pathways | mTOR, mtor |
| GeneCards | ATG4A |
| Human Protein Atlas | ATG4A |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ATG4A"]
N1["Ms"]
N0 -->|"activates"| N1
N2["MAP1LC3B2"]
N0 -->|"causes"| N2
N3["AUTOPHAGY"]
N0 -->|"activates"| N3
N4["Autophagy"]
N0 -->|"activates"| N4
N5["NEURODEGENERATIVE DISORDERS"]
N5 -->|"activates"| N0
N6["VIRAL INFECTIONS"]
N6 -->|"activates"| N0
N7["ATG7"]
N7 -->|"causes"| N0
N8["AND"]
N8 -->|"causes"| N0
N9["GENES"]
N9 -->|"activates"| N0
N10["TBK1"]
N10 -->|"causes"| N0
N11["neurodegeneration"]
N0 -->|"implicated in"| N11
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 pathway
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 gene
class N10 gene| Source | Relation | Type | Str |
|---|---|---|---|
| ATG7 | causes | gene | 0.60 |
| TBK1 | causes | gene | 0.60 |
| ATG4D | associated_with | gene | 0.60 |
| ATG4B | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.60 |
| VIRAL INFECTIONS | activates | gene | 0.60 |
| AND | causes | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ATG4A | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||