Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about atg4c: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATG4C |
| Full Name | Autophagy Related 4C Cysteine Peptidase |
| Chromosome | 19p13.3 |
| Protein Type | Protease |
| Function | encodes a cysteine protease that plays a critical role in the autophagy pathway, the cell's primary mechanism for degrading and recycling damaged organelles, protein aggregates, and intracellular p... |
| Primary Expression | various tissues with relatively higher expression in the brain, heart, and skeletal muscle |
| Molecular Weight | 52 kDa |
| Amino Acids | 371 aa |
| Gene Type | Protein-coding |
| UniProt ID | Q9Y4P5 |
| NCBI Gene ID | 84938 |
| Ensembl ID | ENSG00000125743 |
| OMIM | 604305 |
| GeneCards | ATG4C |
| Human Protein Atlas | ATG4C |
| Associated Diseases | ALS |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
ATG4C["ATG4C"] -->|"associated with"| ALS["ALS"]
ATG4C["ATG4C"] -->|"activates"| Autophagy["Autophagy"]
ATG4C["ATG4C"] -->|"associated with"| ATG4D["ATG4D"]
ATG4C["ATG4C"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
ATG4D["ATG4D"] -->|"associated with"| ATG4C["ATG4C"]
ATG4B["ATG4B"] -->|"associated with"| ATG4C["ATG4C"]
ATG4A["ATG4A"] -->|"associated with"| ATG4C["ATG4C"]
style ATG4C fill:#4a1a6b,stroke:#333,color:#e0e0e0
style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
style ATG4D fill:#4a1a6b,stroke:#333,color:#e0e0e0
style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
style ATG4B fill:#4a1a6b,stroke:#333,color:#e0e0e0
style ATG4A fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 0.65 |
| ATG4D | associated_with | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ATG4C | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATG4D | associated_with | gene | 0.60 |
| ATG4B | associated_with | gene | 0.60 |
| ATG4A | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:ATG4C | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||