Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHD1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CHD1L |
| Full Name | Chromodomain Helicase DNA-Binding Protein 1-Like |
| Chromosome | 1q21.1 |
| Protein Type | SNF2 family chromatin remodeler |
| Function | CHD1L belongs to the SNF2 family of ATP-dependent chromatin remodelers. |
| Primary Expression | neurons and glial cells, with particular enrichment in regions associated with learning and memory |
| Molecular Weight | 110 kDa |
| Pathways | epigenetic regulation |
| GeneCards | CHD1L |
| Human Protein Atlas | CHD1L |
| Chromatin Remodeling | Uses ATP hydrolysis to slide, eject, or restructure nucleosomes, making DNA accessible for transcription, replication, and repair |
| DNA Damage Response | Recruited to sites of DNA double-strand breaks where it promotes chromatin relaxation for repair factor access |
| Transcriptional Regulation | Modulates gene expression by altering chromatin accessibility at promoter and enhancer regions |
| Cell Cycle Regulation | Participates in S-phase progression and mitotic chromosome condensation [@zhang2020] |
| DNA Repair Deficits | CHD1L expression is reduced in AD brain tissue, potentially contributing to accumulated DNA damage in neurons |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHD1L["CHD1L"]
style CHD1L fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
DNMT3A(["DNMT3A"])
TET2["TET2"]
epigenetic_regulation["epigenetic regulation"]
neurodegeneration["neurodegeneration"]
CHD1L -->|"regulates"| DNMT3A
CHD1L -->|"regulates"| TET2
CHD1L -->|"participates_in"| epigenetic_regulation
CHD1L -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class DNMT3A protein
class TET2 gene
class epigenetic_regulation protein
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| DNMT3A | regulates | gene | 0.55 |
| TET2 | regulates | gene | 0.55 |
| epigenetic regulation | participates_in | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CHD1L in their description or question text
No additional research found