Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about epigenetic regulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | epigenetic regulation |
| Summary | Page for Epigenetic Regulation |
| Key Genes/Proteins | DNA, BDNF, HDAC3, DNMT1, protein arginine methyltransferases, TET2 |
| Related Diseases | Alzheimer's disease, neurodegeneration |
| Linked Hypotheses | 9 hypotheses |
Knowledge base pages for this entity
graph TD
epigenetic_regulation["epigenetic regulation"] -->|"regulates"| senescence["senescence"]
style senescence fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
epigenetic_regulation["epigenetic regulation"] -->|"regulates"| liver_brain_axis["liver-brain axis"]
style liver_brain_axis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
epigenetic_regulation["epigenetic regulation"] -->|"active in"| cortex["cortex"]
style cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
epigenetic_regulation["epigenetic regulation"] -->|"crosstalk with"| glutamate_signaling["glutamate signaling"]
style glutamate_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
epigenetic_regulation["epigenetic regulation"] -->|"active in"| microglia["microglia"]
style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
epigenetic_regulation["epigenetic regulation"] -->|"crosstalk with"| synaptic_plasticity["synaptic plasticity"]
style synaptic_plasticity fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
epigenetic_regulation["epigenetic regulation"] -->|"active in"| thalamus["thalamus"]
style thalamus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
DNA["DNA"] -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| epigenetic_regulation["epigenetic regulation"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
BDNF["BDNF"] -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
HDAC3["HDAC3"] -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
style HDAC3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
RNA["RNA"] -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style epigenetic_regulation fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| neural stem cells | active_in | cell_type | 0.90 |
| tumorigenesis | contributes_to | process | 0.90 |
| senescence | regulates | process | 0.82 |
| liver-brain axis | regulates | pathway | 0.70 |
| cortex | active_in | brain_region | 0.70 |
| neurons | active_in | cell_type | 0.70 |
| lipid metabolism | crosstalk_with | pathway | 0.70 |
| glutamate signaling | crosstalk_with | pathway | 0.60 |
| microglia | active_in | cell_type | 0.60 |
| synaptic plasticity | crosstalk_with | pathway | 0.60 |
| thalamus | active_in | brain_region | 0.60 |
| hypothalamus | active_in | brain_region | 0.60 |
| unfolded protein response | crosstalk_with | pathway | 0.60 |
| phagocytosis | mediates | process | 0.60 |
| pyroptosis | mediates | process | 0.60 |
| astrocytes | active_in | cell_type | 0.60 |
| hippocampus | active_in | brain_region | 0.60 |
| ferroptosis | crosstalk_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DNA | participates_in | gene | 0.90 |
| Alzheimer's disease | involves | disease | 0.90 |
| BDNF | participates_in | gene | 0.90 |
| HDAC3 | participates_in | gene | 0.90 |
| DAM microglia | active_in | cell_type | 0.85 |
| neurons | active_in | cell_type | 0.85 |
| DNMT1 | participates_in | gene | 0.85 |
| protein arginine methyltransferases | involved_in | protein | 0.85 |
| TET2 | involved_in | protein | 0.85 |
| RNA | participates_in | gene | 0.80 |
| neurodegeneration | involves | disease | 0.80 |
| AR | participates_in | gene | 0.80 |
| HDAC6 | participates_in | gene | 0.80 |
| BECN1 | participates_in | gene | 0.80 |
| PIK3C3 | participates_in | gene | 0.80 |
| AMPK | participates_in | gene | 0.80 |
| HDAC | participates_in | gene | 0.80 |
| HDAC4 | participates_in | gene | 0.80 |
| HDAC2 | participates_in | gene | 0.80 |
| HDAC1 | participates_in | gene | 0.80 |
| PRMT1 | involved_in | protein | 0.80 |
| HDAC9 | participates_in | gene | 0.80 |
| frontotemporal dementia | involves | disease | 0.80 |
| JAK | participates_in | gene | 0.80 |
| microglia | active_in | cell_type | 0.75 |
| EZH2 | participates_in | gene | 0.75 |
| lactylation | regulates | process | 0.70 |
| aging | involves | disease | 0.70 |
| AKT | participates_in | gene | 0.70 |
| PI3K-AKT-mTOR signaling | crosstalk_with | pathway | 0.70 |
| depression | involves | disease | 0.70 |
| NR3C1 | participates_in | gene | 0.70 |
| DNMT3A | participates_in | gene | 0.70 |
| TP53 | participates_in | gene | 0.70 |
| MAP1LC3B | participates_in | gene | 0.70 |
| GAPDH | participates_in | gene | 0.70 |
| SQSTM1 | participates_in | gene | 0.70 |
| UVRAG | participates_in | gene | 0.70 |
| ULK1 | participates_in | gene | 0.70 |
| ATG | participates_in | gene | 0.70 |
| MTOR | participates_in | gene | 0.70 |
| SIRT1 | participates_in | gene | 0.70 |
| EP300 | participates_in | gene | 0.70 |
| TFEB | participates_in | gene | 0.70 |
| CREB | participates_in | gene | 0.70 |
| Parkinson's disease | involves | disease | 0.70 |
| APP | participates_in | gene | 0.70 |
| RAS | participates_in | gene | 0.70 |
| GBM | participates_in | gene | 0.70 |
| CBP | participates_in | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||