protein

DNMT3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNMT3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

284Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

Page for DNMT3A Protein (DNA Methyltransferase 3A)

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🔬 Protein Info

Gene Symbol	DNMT3A
Full Name	DNA Methyltransferase 3 Alpha
Aliases	DNA Methyltransferase 3A
Chromosome	2p23
Protein Type	Transferase
Function	DNMT3A encodes DNA methyltransferase 3 alpha, a de novo DNA methyltransferase that establishes new DNA methylation patterns during development and in adult tissues.
Primary Expression	neurons during development and in adulthood
Molecular Weight	130 kDa
Pathways	Dna Methylation, Epigenetic
UniProt ID	[Q9Y6K4](https://www.uniprot.org/uniprot/Q9Y6K4)
Ensembl ID	ENSG00000119772
OMIM	602950
GeneCards	DNMT3A
Human Protein Atlas	DNMT3A
Associated Diseases	Als, Alzheimer, Cancer, Cardiovascular, Crohn'S Disease
Known Drugs/Compounds	5-azacytidine, Decitabine, GEMCITABINE
Interactions	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ASXL1, BACE1
SciDEX Hypotheses	DNMT3A-Mediated de novo Methylation Corrects 'Epig Perinatal Epigenetic Reprogramming as AD Preventio
KG Connections	284 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNMT3A Gene

gene · 715 words

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DNMT3A Protein (DNA Methyltransferase 3A)

protein · 855 words

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Pathway Diagram

graph TD
    DNMT3A["DNMT3A"]
    DNMT3A -->|"target for"| Cancer["Cancer"]
    DNMT3A -->|"target for"| Cardiovascular["Cardiovascular"]
    DNMT3A -->|"activates"| Inflammation["Inflammation"]
    DNMT3A -->|"target for"| Alzheimer["Alzheimer"]
    DNMT3A -->|"target for"| Heart_Failure["Heart Failure"]
    DNMT3A -->|"activates"| Als["Als"]
    DNMT3A -->|"target for"| Leukemia["Leukemia"]
    DNMT3A -->|"expressed in"| Ms["Ms"]
    ASXL1["ASXL1"] -->|"activates"| DNMT3A
    SF3B1["SF3B1"] -->|"activates"| DNMT3A
    TET2["TET2"] -->|"activates"| DNMT3A
    TP53["TP53"] -->|"activates"| DNMT3A
    U2AF1["U2AF1"] -->|"activates"| DNMT3A
    INFLAMMATION["INFLAMMATION"] -->|"activates"| DNMT3A
    TFE3["TFE3"] -->|"regulates"| DNMT3A
    DOT1L["DOT1L"] -->|"regulates"| DNMT3A
    AMPK["AMPK"] -->|"regulates"| DNMT3A
    TFEB["TFEB"] -->|"regulates"| DNMT3A

Outgoing (181)

Target	Relation	Type	Str
Epigenetics	involved_in	process	0.95
EPIGENETIC MODIFICATION	regulates	phenotype	0.90
Crohn'S Disease	associated_with	disease	0.85
Crohn's Disease	risk_factor_for	disease	0.85
Chronic Inflammation	regulates	process	0.85
Leukemia	associated_with	disease	0.80
Immune Response	regulates	process	0.80
Immune Responses	modifies	process	0.80
Chronic Inflammation	promotes	process	0.80
immune response	modulates	process	0.80
Clonal Hematopoiesis	contributes_to	process	0.80
NEUROINFLAMMATION	regulates	entity	0.75
BRAF	interacts_with	gene	0.75
BACE1	inhibits	gene	0.70
DNA_methylation	catalyzes	pathway	0.70
epigenetic regulation	participates_in	pathway	0.70
FOXO3	regulates	gene	0.70
Autism	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cardiovascular	causes	disease	0.65
Als	causes	disease	0.65
Cancer	causes	disease	0.65
Inflammation	causes	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	associated_with	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Heart Failure	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Osteoporosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Heart Failure	activates	disease	0.65
Als	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65

Incoming (103)

Source	Relation	Type	Str
h-e5f1182b	targets	hypothesis	0.90
Decitabine	inhibits	drug	0.90
5-azacytidine	inhibits	drug	0.90
WNT SIGNALING	regulates	pathway	0.70
DNMT1	stabilizes	gene	0.70
CREB	protects_against	gene	0.70
DNMT1	regulates	gene	0.65
DNMT1	associated_with	gene	0.65
U2AF1	activates	gene	0.60
DNMT1	expressed_in	gene	0.60
IL10	associated_with	gene	0.60
TET2	associated_with	gene	0.60
TET2	regulates	gene	0.60
TFAM	regulates	gene	0.60
TET2	activates	gene	0.60
TYK2	associated_with	gene	0.60
IL10	regulates	gene	0.60
TFEB	regulates	gene	0.60
SF3B1	activates	gene	0.60
MMP2	regulates	gene	0.60
NPM1	associated_with	gene	0.60
NCAM1	expressed_in	gene	0.60
MMP9	regulates	gene	0.60
TP53	associated_with	gene	0.60
COMT	expressed_in	gene	0.60
DLGAP2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
ARG1	expressed_in	gene	0.60
DRD2	expressed_in	gene	0.60
PIK3CA	associated_with	gene	0.60
IL6	regulates	gene	0.60
DOT1L	regulates	gene	0.60
MYC	activates	gene	0.60
OCT4	activates	gene	0.60
SOX2	activates	gene	0.60
KLF4	activates	gene	0.60
HDAC10	activates	gene	0.60
HDAC1	activates	gene	0.60
DNMT1	activates	gene	0.60
BAX	expressed_in	gene	0.60
DNMT3B	activates	gene	0.60
CASP3	activates	gene	0.60
PENK	expressed_in	gene	0.60
SMAD3	associated_with	gene	0.60
ADRA2A	expressed_in	gene	0.60
DNMT3B	expressed_in	gene	0.60
CGAS	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
AKT1	expressed_in	gene	0.60
IDH1	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Sca	0.460	neurodegeneration	Investigate mechanisms of epigenetic rep
Perinatal Epigenetic Reprogramming as AD Prevention	0.000	-	Neuroinflammation and microglial priming