Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CTSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CTSE |
| Full Name | Cathepsin E |
| Chromosome | 1q31.3 |
| Protein Type | Protease |
| Function | is a gene located on chromosome 1q31. |
| Subcellular Localization | endosomal compartments and the trans-Golgi network rather than in lysosomes. This subcellular distribution suggests dist |
| Amino Acids | 426 aa |
| UniProt ID | [P10111](https://www.uniprot.org/uniprot/P10111) |
| Ensembl ID | ENSG00000105638 |
| GeneCards | CTSE |
| Human Protein Atlas | CTSE |
| Immune cells | Highest expression in macrophages, monocytes, and dendritic cells |
| Gastrointestinal tract | Abundant in gastric mucosa and intestinal epithelium |
| Brain | Low to moderate expression in neurons, microglia, and astrocytes |
| Microglial activation | Cathepsin E in microglia contributes to the inflammatory cascade by regulating cytokine production and inflammasome activation |
| Associated Diseases | neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CTSE"]
N1["Menin"]
N1 -->|"regulates"| N0
N2["CTSB"]
N2 -->|"regulates"| N0
N3["MLL"]
N0 -->|"regulates"| N3
N4["TFE3"]
N0 -->|"regulates"| N4
N5["neurodegeneration"]
N0 -->|"implicated in"| N5
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class N0 gene
class N1 protein
class N2 gene
class N3 gene
class N4 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||