TFE3

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFE3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TFE3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Aging, Als. Connected to 302 entities in the SciDEX knowledge graph.

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graph TD
    TFE3["TFE3"] -->|"Interacts With"| Cancer["Cancer"]
    TFE3["TFE3"] -->|"Interacts With"| Als["Als"]
    TFE3["TFE3"] -->|"Interacts With"| Ms["Ms"]
    TFE3["TFE3"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    TFE3["TFE3"] -->|"Therapeutic Target"| Multiple_Sclerosis["Multiple Sclerosis"]
    TFE3["TFE3"] -->|"Therapeutic Target"| Alzheimer["Alzheimer"]
    TFE3["TFE3"] -->|"Therapeutic Target"| Parkinson["Parkinson"]
    TFE3["TFE3"] -->|"Activates"| Hepatitis["Hepatitis"]
    AMBRA1["AMBRA1"] -->|"Inhibits"| TFE3["TFE3"]
    OPTN["OPTN"] -->|"Interacts With"| TFE3["TFE3"]
    CASP3["CASP3"] -->|"Interacts With"| TFE3["TFE3"]
    AKT1["AKT1"] -->|"Interacts With"| TFE3["TFE3"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| TFE3["TFE3"]
    style TFE3 fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Multiple_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style AMBRA1 fill:#0d47a1,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0