gene

CTSB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

816Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CTSB is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Aging, Als. Connected to 311 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CTSB
Full Name	Cathepsin B
Chromosome	8p23.1
Subcellular Localization	\| Compartment \| Function \|
Molecular Weight	26 kDa
Amino Acids	339 aa
Exons	13
Pathways	Autophagy
UniProt ID	P07846
NCBI Gene ID	1508
Ensembl ID	ENSG00000164733
OMIM	116810
GeneCards	CTSB
Human Protein Atlas	CTSB
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, APOPTOSIS
Known Drugs/Compounds	rapamycin, tannic acid
Interactions	ACTB, Actin, AGING, AIF1, AKT, ALS
SciDEX Hypotheses	Selective cathepsin B inhibition prevents cathepsi
KG Connections	815 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTSB — AlphaFold P07846 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    TFEB["TFEB
Transcription Factor"]
    SLAMF7["SLAMF7
Signaling Protein"]
    CTSB["CTSB
Cathepsin B
Lysosomal Protease"]
    
    ATG12["ATG12
Autophagy Protein"]
    TPP1["TPP1
Lysosomal Enzyme"]
    GRN["GRN
Progranulin
Growth Factor"]
    
    Phagocytosis["Phagocytosis
Pathway"]
    Complement["Complement
Pathway"]
    C1QA["C1QA
Complement
Component"]
    SPP1["SPP1
Osteopontin
Inflammatory Marker"]
    
    Neurodegeneration["Neurodegeneration
Pathological Process"]
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    Huntington["Huntington's
Disease"]
    
    TFEB -->|"upregulates"| CTSB
    SLAMF7 -->|"activates"| CTSB
    
    CTSB -->|"activates"| ATG12
    CTSB -->|"associated_with"| TPP1
    CTSB -->|"activates"| GRN
    
    CTSB -->|"activates"| Phagocytosis
    CTSB -->|"activates"| Complement
    CTSB -->|"activates"| C1QA
    CTSB -->|"activates"| SPP1
    
    CTSB -->|"activates"| Neurodegeneration
    CTSB -->|"associated_with"| Alzheimer
    CTSB -->|"associated_with"| Parkinson
    CTSB -->|"associated_with"| ALS
    CTSB -->|"associated_with"| Huntington
    
    style CTSB fill:#006494
    style TFEB fill:#4a1a6b
    style SLAMF7 fill:#4a1a6b
    style ATG12 fill:#1b5e20
    style TPP1 fill:#1b5e20
    style GRN fill:#1b5e20
    style Phagocytosis fill:#1b5e20
    style Complement fill:#ef5350
    style C1QA fill:#ef5350
    style SPP1 fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style Huntington fill:#5d4400

Outgoing (525)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CTSB	data_in	dataset_row	0.00
CTSB	encodes	protein	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
hepato-cardiotoxicity	mediates	phenotype	0.95
Vandetanib-Induced Hepato-Cardiotoxicity	mediates	phenotype	0.95
MCOLN1	degrades	gene	0.90
therapeutic_target	involved_in	process	0.88
neural stem cells	activates	cell_type	0.80
MCOLN1	interacts_with	gene	0.80
Alzheimer	activates	disease	0.75
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
LC3	associated_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
GFP	activates	gene	0.70
CTSD	interacts_with	gene	0.70
LAMP1	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
ULK1	interacts_with	gene	0.70
neurons	activates	cell_type	0.70
GFP	interacts_with	gene	0.70
AMPK signaling	participates_in	pathway	0.70
P62	associated_with	gene	0.70
Autophagy	activates	pathway	0.70
LC3	interacts_with	gene	0.70
Parkinson's disease	associated_with	disease	0.70
ULK1	activates	gene	0.70
MAP1LC3B	interacts_with	gene	0.70
SQSTM1	interacts_with	gene	0.70
GAPDH	interacts_with	gene	0.70
neural stem cells	interacts_with	cell_type	0.70
LGALS3	interacts_with	gene	0.70
LAMP1	interacts_with	gene	0.70
APOPTOSIS	causes	phenotype	0.70
TFEB	interacts_with	gene	0.70
Tumor	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Als	therapeutic_target	disease	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ferroptosis	associated_with	disease	0.65
DOPAMINERGIC NEURONS	activates	cell_type	0.65
Cancer	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
NLRP3	regulates	gene	0.65
Diabetes	associated_with	disease	0.65
LYSOSOMAL DYSFUNCTION	regulates	phenotype	0.65
Stroke	inhibits	disease	0.65
Als	regulates	disease	0.65

Incoming (291)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CTSB	data_in	dataset_row	0.00
CTSB	encodes	gene	0.00
ds-83b31ef18d49	data_in	dataset	1.00
proteins-cathepsin-b-protein	describes	wiki	1.00
Menin	regulates	protein	0.95
tannic acid	binds	compound	0.90
Vandetanib	upregulates	drug	0.90
STAT3	upregulates	gene	0.90
SPP1	upregulates	gene	0.90
TFEB	activates	gene	0.85
TFEB	upregulates	protein	0.85
SLAMF7	activates	gene	0.80
ALZHEIMER DISEASE	associated_with	gene	0.80
AMPK	activates	gene	0.80
SQSTM1	associated_with	gene	0.70
INFLAMMATION	activates	gene	0.70
AMPK	interacts_with	gene	0.70
ALZHEIMER	activates	gene	0.70
rapamycin	targets	drug	0.70
MACROPHAGE	produces	cell_type	0.65
BAG3	regulates	entity	0.60
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
C1QA	regulates	entity	0.60
ATG10	regulates	entity	0.60
ATG12	regulates	entity	0.60
CTSH	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
CST3	activates	gene	0.60
NPTX1	inhibits	gene	0.60
SERPINA3	inhibits	gene	0.60
NRXN2	inhibits	gene	0.60
VGF	inhibits	gene	0.60
ALDH2	regulates	gene	0.60
TARDBP	regulates	gene	0.60
LGALS1	regulates	gene	0.60
FASN	regulates	gene	0.60
CDK1	regulates	gene	0.60
SORL1	associated_with	gene	0.60
GRN	associated_with	gene	0.60
C1QA	expressed_in	gene	0.60
ATR	activates	gene	0.60
ABI3	expressed_in	gene	0.60
AGING	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DMSO	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CTSB in their description or question text

No additional research found