CTSB

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CTSB is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Aging, Als. Connected to 311 entities in the SciDEX knowledge graph.

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flowchart TD
    TFEB["TFEB<br/>Transcription Factor"]
    SLAMF7["SLAMF7<br/>Signaling Protein"]
    CTSB["CTSB<br/>Cathepsin B<br/>Lysosomal Protease"]
    
    ATG12["ATG12<br/>Autophagy Protein"]
    TPP1["TPP1<br/>Lysosomal Enzyme"]
    GRN["GRN<br/>Progranulin<br/>Growth Factor"]
    
    Phagocytosis["Phagocytosis<br/>Pathway"]
    Complement["Complement<br/>Pathway"]
    C1QA["C1QA<br/>Complement<br/>Component"]
    SPP1["SPP1<br/>Osteopontin<br/>Inflammatory Marker"]
    
    Neurodegeneration["Neurodegeneration<br/>Pathological Process"]
    Alzheimer["Alzheimer's<br/>Disease"]
    Parkinson["Parkinson's<br/>Disease"]
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    Huntington["Huntington's<br/>Disease"]
    
    TFEB --|"upregulates"|--> CTSB
    SLAMF7 --|"activates"|--> CTSB
    
    CTSB --|"activates"|--> ATG12
    CTSB --|"associated_with"|--> TPP1
    CTSB --|"activates"|--> GRN
    
    CTSB --|"activates"|--> Phagocytosis
    CTSB --|"activates"|--> Complement
    CTSB --|"activates"|--> C1QA
    CTSB --|"activates"|--> SPP1
    
    CTSB --|"activates"|--> Neurodegeneration
    CTSB --|"associated_with"|--> Alzheimer
    CTSB --|"associated_with"|--> Parkinson
    CTSB --|"associated_with"|--> ALS
    CTSB --|"associated_with"|--> Huntington
    
    style CTSB fill:#006494
    style TFEB fill:#4a1a6b
    style SLAMF7 fill:#4a1a6b
    style ATG12 fill:#1b5e20
    style TPP1 fill:#1b5e20
    style GRN fill:#1b5e20
    style Phagocytosis fill:#1b5e20
    style Complement fill:#ef5350
    style C1QA fill:#ef5350
    style SPP1 fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style Huntington fill:#5d4400