KDM4C

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM4C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

KDM4C

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graph TD
    KDM4C["KDM4C<br/>Histone Demethylase"]
    IDH1["IDH1<br/>Isocitrate Dehydrogenase"]
    H3K9me3["H3K9me3<br/>Trimethyl Histone H3"]
    H3K36me3["H3K36me3<br/>Trimethyl Histone H3"]
    chromatin_remodeling["Chromatin Remodeling"]
    gene_expression["Neuronal Gene Expression"]
    DNA_damage["DNA Damage Response"]
    oxidative_stress["Oxidative Stress"]
    mitochondrial_dysfunction["Mitochondrial Dysfunction"]
    neuronal_apoptosis["Neuronal Apoptosis"]
    protein_aggregation["Protein Aggregation"]
    synaptic_dysfunction["Synaptic Dysfunction"]
    neurodegeneration["Neurodegeneration"]
    alzheimers["Alzheimer's Disease"]
    parkinsons["Parkinson's Disease"]

    IDH1 -->|"upregulates"| KDM4C
    KDM4C -->|"demethylates"| H3K9me3
    KDM4C -->|"demethylates"| H3K36me3
    H3K9me3 -->|"regulates"| chromatin_remodeling
    H3K36me3 -->|"regulates"| chromatin_remodeling
    chromatin_remodeling -->|"modulates"| gene_expression
    KDM4C -->|"disrupts"| DNA_damage
    DNA_damage -->|"triggers"| oxidative_stress
    oxidative_stress -->|"causes"| mitochondrial_dysfunction
    mitochondrial_dysfunction -->|"leads to"| neuronal_apoptosis
    gene_expression -->|"affects"| protein_aggregation
    protein_aggregation -->|"impairs"| synaptic_dysfunction
    neuronal_apoptosis -->|"contributes to"| neurodegeneration
    synaptic_dysfunction -->|"contributes to"| neurodegeneration
    neurodegeneration -->|"manifests as"| alzheimers
    neurodegeneration -->|"manifests as"| parkinsons

    style KDM4C fill:#1a3a4a,stroke:#4fc3f7
    style chromatin_remodeling fill:#1a3a2a,stroke:#81c784
    style gene_expression fill:#1a3a2a,stroke:#81c784
    style IDH1 fill:#2a1a3a,stroke:#ce93d8
    style H3K9me3 fill:#2a1a3a,stroke:#ce93d8
    style H3K36me3 fill:#2a1a3a,stroke:#ce93d8
    style DNA_damage fill:#3a1a1a,stroke:#ef5350
    style oxidative_stress fill:#3a1a1a,stroke:#ef5350
    style mitochondrial_dysfunction fill:#3a1a1a,stroke:#ef5350
    style neuronal_apoptosis fill:#3a1a1a,stroke:#ef5350
    style protein_aggregation fill:#3a1a1a,stroke:#ef5350
    style synaptic_dysfunction fill:#3a1a1a,stroke:#ef5350
    style neurodegeneration fill:#3a2a1a,stroke:#ffa726
    style alzheimers fill:#3a2a1a,stroke:#ffa726
    style parkinsons fill:#3a2a1a,stroke:#ffa726