gene 1,620 words KG: KDM4A 2026-03-28
kind:genesection:genesstate:publishedtopic:epigeneticstopic:alzheimerstopic:parkinsons
Contents

KDM4A - Lysine Specific Demethylase 4A

🧬 Gene Info
Gene SymbolKDM4A
Full NameLysine Specific Demethylase 4A
AliasesKDM4A gene encoding JMJD2A, Lysine Specific Demethylase 4A (JMJD2A
Chromosome1p34.2
Protein FamilyJMJD2 family (Jumonji C domain demethylase)
Functionencodes a lysine-specific histone demethylase that catalyzes the removal of methyl groups from histone lysine residues, primarily H3K9me3 and H3K36me3.
Amino Acids1054 aa
Exons22
UniProt IDO75173
NCBI Gene ID9682
Ensembl IDENSG00000133195
OMIM605095
GeneCardsKDM4A
Human Protein AtlasKDM4A
Associated DiseasesAls, Cancer
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (6)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived

See Also (9)

Packard Center for ALS Research
institution · KG edge: associated_with
TP53 Gene
gene · KG edge: associated_with
MITF Gene — Microphthalmia-Associated Transcription Fac
gene · KG edge: associated_with
IDH1 Gene - Isocitrate Dehydrogenase 1
gene · KG edge: upregulates
HSPA1A Gene
gene · KG edge: associated_with

Knowledge Graph (11 edges)

KDM4A associated_with FGFR3
KDM4A associated_with TP53
KDM4A associated_with BICD2
KDM4A associated_with MITF
KDM4A associated_with HSPA1A
KDM4A associated_with BRCA2
KDM4A associated_with KRAS
KDM4A associated_with CANCER
KDM4A associated_with Als
KDM4A associated_with Cancer