IDH1

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

IDH1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with AD, ADH, ALI. Connected to 251 entities in the SciDEX knowledge graph.

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flowchart TD
    IDH1["IDH1<br/>(Isocitrate Dehydrogenase 1)"]
    
    MetabolicChanges["Metabolic<br/>Changes"]
    AlphaKG["alpha-Ketoglutarate<br/>Production"]
    TwoHG["2-Hydroxyglutarate<br/>(Oncometabolite)"]
    
    Neuroinflammation["Neuroinflammation"]
    Inflammation["Systemic<br/>Inflammation"]
    OxidativeStress["Oxidative<br/>Stress"]
    
    Alzheimer["Alzheimer's<br/>Disease"]
    Parkinson["Parkinson's<br/>Disease"]
    ALS["Amyotrophic Lateral<br/>Sclerosis"]
    MS["Multiple<br/>Sclerosis"]
    Neurodegeneration["Neurodegeneration"]
    
    Glioma["Glioma"]
    Glioblastoma["Glioblastoma"]
    Cancer["Cancer"]
    
    TherapeuticTarget["Therapeutic<br/>Target"]
    Biomarker["Disease<br/>Biomarker"]
    
    IDH1 --|"modulates"|--> MetabolicChanges
    IDH1 --|"produces"|--> AlphaKG
    IDH1 --|"mutation produces"|--> TwoHG
    
    MetabolicChanges --|"leads to"|--> OxidativeStress
    TwoHG --|"promotes"|--> Neuroinflammation
    
    IDH1 --|"activates"|--> Neuroinflammation
    IDH1 --|"activates"|--> Inflammation
    Neuroinflammation --|"contributes to"|--> Neurodegeneration
    
    IDH1 --|"activates"|--> Alzheimer
    IDH1 --|"activates"|--> Parkinson
    IDH1 --|"associated with"|--> ALS
    IDH1 --|"associated with"|--> MS
    
    IDH1 --|"associated with"|--> Glioma
    IDH1 --|"associated with"|--> Glioblastoma
    IDH1 --|"therapeutic target"|--> Cancer
    
    IDH1 --|"serves as"|--> Biomarker
    IDH1 --|"serves as"|--> TherapeuticTarget
    
    style IDH1 fill:#006494
    style AlphaKG fill:#1b5e20
    style TwoHG fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Inflammation fill:#ef5350
    style OxidativeStress fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style TherapeuticTarget fill:#1b5e20
    style Biomarker fill:#4a1a6b