gene 2,794 words KG: SETD1A
Contents

SETD1A Gene

🧬 Gene Info
Gene SymbolSETD1A
Full NameSET Domain Containing 1A, Histone Lysine Methyltransferase
AliasesKMT2F, SET1, SET1A
Chromosome16p11.2
Protein TypeTransferase
Functionencodes a histone H3 lysine 4 (H3K4) methyltransferase that is the catalytic subunit of the SETD1A/COMPASS complex.
Gene TypeProtein-coding
UniProt IDO15047
Ensembl IDENSG00000099381
OMIM611052
GeneCardsSETD1A
Human Protein AtlasSETD1A
HGNC29010
Entrez Gene9739
p.R913Nonsense
Associated Diseasesschizophrenia
InteractionsKMT2B, SHANK3, KMT2D, CACNA1G, KMT2A, ANK3
KG Connections30 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.49

Related Analyses (2)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40
Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40

See Also (8)

SHANK3 - SH3 and Multiple Ankyrin Repeat Domains 3
gene · KG edge: inhibits
KMT2D — Lysine Methyltransferase 2D
gene · KG edge: inhibits
KMT2B — lysine methyltransferase 2B
gene · KG edge: inhibits
KMT2A — lysine methyltransferase 2A
gene · KG edge: inhibits
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

SETD1A expressed_in GAIN
SETD1A inhibits KMT2B
SETD1A inhibits SHANK3
SETD1A inhibits KMT2D
SETD1A inhibits CACNA1G
SETD1A inhibits KMT2A
SETD1A regulates schizophrenia
SETD1A interacts_with schizophrenia
SETD1A associated_with schizophrenia
SETD1A implicated_in schizophrenia