Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NIPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NIPA1 |
| Full Name | Non-imprinted in Prader-Willi/Angelman Syndrome 1 |
| Chromosome | 9q21.13 |
| Protein Type | Transporter |
| Function | encodes a magnesium transporter protein that plays critical roles in neuronal function, synaptic transmission, and intracellular magnesium homeostasis. |
| Amino Acids | 317 aa |
| UniProt ID | [Q9BUE2](https://www.uniprot.org/uniprot/Q9BUE2) |
| Ensembl ID | ENSG00000139970 |
| GeneCards | NIPA1 |
| Human Protein Atlas | NIPA1 |
| Ion Specificity | Highly selective for magnesium over other divalent cations |
| Transport Mechanism | Electrogenic Mg²⁺/H⁺ antiport mechanism |
| pH Sensitivity | Activity modulated by intracellular pH |
| Regulation | Controlled by cellular magnesium status and neuronal activity |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["NIPA1"]
N1["ATXN1"]
N1 -->|"associated with"| N0
N2["ATXN2"]
N2 -->|"associated with"| N0
N3["UNC13A"]
N0 -->|"associated with"| N3
N4["neurodegeneration"]
N0 -->|"implicated in"| N4
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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class N0 gene
class N1 gene
class N2 gene
class N3 gene| Target | Relation | Type | Str |
|---|---|---|---|
| UNC13A | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||