gene

UNC13A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UNC13A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

201Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	UNC13A
Full Name	Unc-13 Homolog A
Aliases	Munc13-1
Chromosome	19p13.11
Function	Synaptic vesicle priming factor essential for neurotransmitter release
Primary Expression	Presynaptic terminals, Motor Neurons, Cortical Neurons, Hippocampus
Molecular Weight	194.3 kDa
Amino Acids	1703
Pathways	Synaptic vesicle exocytosis, Neurotransmitter release
UniProt ID	Q9UPW8
Ensembl ID	ENSG00000130477
GeneCards	UNC13A
Human Protein Atlas	UNC13A
Associated Diseases	ALS, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Depletion
Interactions	TDP-43, NEURODEGENERATIVE DISEASES, SYNAPSE, DEMENTIA, amyotrophic lateral sclerosis, RNA
KG Connections	198 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: UNC13A — AlphaFold Q9UPW8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UNC13A["UNC13A"] -->|"associated"| Depletion["Depletion"]
    style Depletion fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    UNC13A["UNC13A"] -->|"risk factor for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    style Amyotrophic_Lateral_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    UNC13A["UNC13A"] -->|"associated"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    UNC13A["UNC13A"] -->|"associated"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    UNC13A["UNC13A"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    UNC13A["UNC13A"] -->|"associated"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    UNC13A["UNC13A"] -->|"associated"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    TDP_43["TDP-43"] -->|"regulates"| UNC13A["UNC13A"]
    style TDP_43 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    TDP43["TDP43"] -->|"regulates"| UNC13A["UNC13A"]
    style TDP43 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    TARDBP["TARDBP"] -->|"regulates"| UNC13A["UNC13A"]
    style TARDBP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ALS_risk_SNPs["ALS-risk SNPs"] -->|"causes"| UNC13A["UNC13A"]
    style ALS_risk_SNPs fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    C3AR1["C3AR1"] -->|"regulates"| UNC13A["UNC13A"]
    style C3AR1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style UNC13A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (109)

Target	Relation	Type	Str
mis-splicing	involved_in	process	0.93
Frontotemporal Dementia	risk_factor_for	disease	0.90
Depletion	associated_with	phenotype	0.88
TDP-43 Pathology	biomarker_for	phenotype	0.88
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.88
Amyotrophic Lateral Sclerosis	risk_factor_for	disease	0.87
Cryptic Donor Splice Site	associated_with	biomarker	0.85
Protein Depletion	involved_in	mechanism	0.85
Cryptic Splicing	involved_in	process	0.85
C9orf72 Hexanucleotide Repeat Expansion	modulates	phenotype	0.85
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.85
ALS	risk_factor_for	disease	0.85
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Dementia	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Dementia	implicated_in	disease	0.65
Ftd	expressed_in	disease	0.65
Als	causes	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
ANO9	regulates	gene	0.60
TBK1	regulates	gene	0.60
TDP43	expressed_in	gene	0.60
TDP-43	causes	gene	0.60
TDP-43	expressed_in	gene	0.60
RBPJL	regulates	gene	0.60
C3AR1	regulates	gene	0.60
GRN	associated_with	gene	0.60
TDP-43	inhibits	gene	0.60
TBK1	associated_with	gene	0.60
Rb	regulates	protein	0.60
C9ORF72	associated_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
neurodegeneration	targets	disease	0.60

Incoming (92)

Source	Relation	Type	Str
TDP-43	regulates	protein	0.95
TDP43	regulates	protein	0.95
TARDBP	regulates	gene	0.95
TDP-43	inhibits	protein	0.95
TDP-43	causes	protein	0.92
TARDBP	drives	gene	0.92
ALS-risk SNPs	causes	biomarker	0.90
TDP43	causes	protein	0.90
Als-Risk Snps	associated_with	biomarker	0.90
ALS-risk SNP	regulates	genetic_variant	0.90
TDP43	downregulates	protein	0.89
ALS-risk SNPs	associated_with	biomarker	0.88
TARDBP	causes	gene	0.88
Mis-Splicing	causes	mechanism	0.87
ALS-risk SNPs	downregulates	biomarker	0.85
Als-Risk Snps	regulates	biomarker	0.85
ALS-risk SNPs	drives	compound	0.85
ALS-risk SNPs	regulates	genetic_variant	0.80
ALS-RISK SNPS	regulates	genetic_variant	0.80
ALS-RISK SNPS	causes	genetic_variant	0.80
TDP-43	targets	gene	0.65
STMN2	targets	gene	0.65
RNA	targets	gene	0.65
C3AR1	regulates	gene	0.60
RBPJL	regulates	gene	0.60
TBK1	implicated_in	gene	0.60
ANO9	implicated_in	gene	0.60
RBPJL	implicated_in	gene	0.60
C3AR1	implicated_in	gene	0.60
TBK1	regulates	gene	0.60
TBK1	associated_with	gene	0.60
C9ORF72	associated_with	gene	0.60
TDP-43	expressed_in	gene	0.60
TDP43	expressed_in	gene	0.60
ANO9	regulates	gene	0.60
GRN	associated_with	gene	0.60
ATXN1	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
NIPA1	associated_with	gene	0.60
STMN2	co_expressed_with	gene	0.60
STMN2	inhibits	gene	0.60
GENES	regulates	gene	0.60
DNA	regulates	gene	0.60
ALS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

UNC13A

Understanding Entity Pages

Wiki Pages (21)

UNC13A (Unc-13 Homolog A)

Oligodendrocytes

ftd-tdp-pathology

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Splice-Modulating Therapies for Neurodegeneration

Motor Neuron Disease (MND)

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Amyotrophic Lateral Sclerosis (ALS)

ftd-tdp43-pathway

ALS RNA Metabolism and Proteostasis Failure

SOD1 Protein

Stathmin-2 (SCG10)

Synaptic Vesicle Trafficking

TAR DNA-Binding Protein 43 (TDP-43)

ALS Progression Trajectories

tdp-43-fus-rna-proteinopathy-comparison

UNC13B — UNC13 Homolog B (Munc13-2)

Synaptic Vesicle Cycle in Neurodegeneration

Protein Aggregation in Neurodegeneration