gene

ATXN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATXN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

340Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATXN2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, treats. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATXN2
Full Name	ATXN2
Aliases	Ataxin-2
Chromosome	12q24.12
Protein Type	Gene
Function	Translational regulation — Associates with actively translating polysomes
Molecular Weight	140 kDa
Amino Acids	318 aa
Exons	32
Pathways	Apoptosis, Autophagy
NCBI Gene ID	Search NCBI
GeneCards	ATXN2
Human Protein Atlas	ATXN2
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis, Ataxia, Dementia, FRONTOTEMPORAL DEMENTIA
Known Drugs/Compounds	Antisense Oligonucleotides, levodopa, rapamycin
Interactions	LRRK2, ATP13A2, VPS35, EIF4G1, TDP-43, MTOR
KG Connections	340 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATXN2["<b>ATXN2</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    ATXN2 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    Als{"Als"}
    ATXN2 -->|"associated with"| Als
    Ms{"Ms"}
    ATXN2 -->|"associated with"| Ms
    ATXN2 -->|"therapeutic target"| Als
    ATXN2 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Neurodegeneration{"Neurodegeneration"}
    ATXN2 -->|"regulates"| Neurodegeneration
    ATXN2 -->|"regulates"| Als
    Ataxia{"Ataxia"}
    ATXN2 -->|"associated with"| Ataxia
    Aging{"Aging"}
    ATXN2 -->|"regulates"| Aging
    ATXN2 -->|"regulates"| Ms
    ATXN2 -->|"therapeutic target"| Ms
    Parkinson{"Parkinson"}
    ATXN2 -->|"activates"| Parkinson
    NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
    NORMAL_TENSION_GLAUCOMA -->|"associated with"| ATXN2
    CHAT["CHAT"]
    CHAT -->|"associated with"| ATXN2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| ATXN2
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"therapeutic target"| ATXN2
    style ATXN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (275)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	risk_factor_for	disease	0.95
ALS	risk_factor_for	disease	0.95
Tdp-43	suppresses	protein	0.95
TDP-43 Pathology	contributes_to	phenotype	0.90
Tdp-43 Toxicity	associated_with	mechanism	0.90
TARDBP	suppresses	gene	0.90
TDP-43 toxicity	suppresses	phenotype	0.90
Motor Neuron Death	involved_in	process	0.85
TDP-43 Pathology	associated_with	phenotype	0.85
TDP-43 Toxicity	modulates	phenotype	0.85
Als Pathogenesis	contributes_to	process	0.85
lifespan	modulates	phenotype	0.85
TDP-43-MEDIATED NEURODEGENERATION	contributes_to	biological_process	0.82
Lifespan	regulates	phenotype	0.80
Stress Granules	regulates	process	0.80
PINK1	regulates	gene	0.80
neurons	expressed_in	cell_type	0.80
STAU1	associated_with	gene	0.80
Amyotrophic Lateral Sclerosis	associated_with	disease	0.80
TDP-43	interacts_with	protein	0.75
Motor Neurons	expressed_in	cell_type	0.75
Als	therapeutic_target	disease	0.75
neurodegeneration	causes	disease	0.70
neurodegeneration	regulates	disease	0.70
ATXN3	causes	gene	0.70
TDP43	interacts_with	protein	0.70
RNP condensate motility	regulates	process	0.70
ALS	therapeutic_target	gene	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	interacts_with	disease	0.70
Huntington's disease	causes	disease	0.70
Spinal Muscular Atrophy	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	regulates	disease	0.65
Ataxia	associated_with	disease	0.65
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Ataxia	expressed_in	disease	0.65
Als	treats	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Huntington	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	causes	disease	0.65

Incoming (65)

Source	Relation	Type	Str
Antisense Oligonucleotides	targets	drug	0.85
ATXN1	causes	gene	0.70
ALS	implicated_in	gene	0.70
CHAT	associated_with	gene	0.60
C9ORF72	treats	gene	0.60
FUS	treats	gene	0.60
SOD1	treats	gene	0.60
SOD1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
FUS	co_expressed_with	protein	0.60
TDP-43	activates	gene	0.60
OPA1	inhibits	gene	0.60
TBC1D24	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
FUS	associated_with	gene	0.60
MTOR	inhibits	gene	0.60
PARK7	expressed_in	gene	0.60
PLIN4	encodes	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
BID	expressed_in	gene	0.60
CCNF	expressed_in	gene	0.60
MAPT	associated_with	gene	0.60
SMN	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
HNRNPA1	associated_with	gene	0.60
CDKN1A	expressed_in	gene	0.60
levodopa	targets	drug	0.60
ATP13A2	associated_with	gene	0.60
ATXN1	associated_with	gene	0.60
NORMAL TENSION GLAUCOMA	associated_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	treats	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALS	treats	gene	0.60
SOD1 MUTATIONS	treats	gene	0.60
ALS	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
NEURON	therapeutic_target	gene	0.60
ALS	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
FTLD	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATXN2

Understanding Entity Pages

Summary

Wiki Pages (21)

ATXN2 Gene

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

rankings

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Splice-Modulating Therapies for Neurodegeneration

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

RNA Therapeutics for Neurodegeneration Investment Landscape

amiloride-als

Amyotrophic Lateral Sclerosis (ALS)

Spinocerebellar Ataxia Type 7 (SCA7)

Viral Vector Delivery Investment Landscape for Neurodegeneration

RNA-Targeted Therapies in Neurodegeneration

aav-gene-therapy-neurodegeneration

ALS Pipeline

Huntington Disease-Like Syndromes (HDL)

SOD1 Protein

Cerebellar Degeneration Pathway

Cerebellar Parallel Fibers

C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chain