gene

ATXN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATXN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

326Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ATXN2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, treats. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATXN2
Aliases	Ataxin-2
Chromosome	12q24.12
Function	Translational regulation — Associates with actively translating polysomes
Molecular Weight	140 kDa
Amino Acids	318 aa
Exons	32
Pathways	Apoptosis, Autophagy
GeneCards	ATXN2
Human Protein Atlas	ATXN2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, dementia
Known Drugs/Compounds	Antisense Oligonucleotides, levodopa, rapamycin
Interactions	ALS, AND, ATP13A2, ATXN3, C9ORF72, DNA
SciDEX Hypotheses	Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to ATXN2 Antisense Oligonucleotides Reduce Dipeptide
KG Connections	326 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATXN2["ATXN2"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    ATXN2 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    Als{"Als"}
    ATXN2 -->|"associated with"| Als
    Ms{"Ms"}
    ATXN2 -->|"associated with"| Ms
    ATXN2 -->|"therapeutic target"| Als
    ATXN2 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Neurodegeneration{"Neurodegeneration"}
    ATXN2 -->|"regulates"| Neurodegeneration
    ATXN2 -->|"regulates"| Als
    Ataxia{"Ataxia"}
    ATXN2 -->|"associated with"| Ataxia
    Aging{"Aging"}
    ATXN2 -->|"regulates"| Aging
    ATXN2 -->|"regulates"| Ms
    ATXN2 -->|"therapeutic target"| Ms
    Parkinson{"Parkinson"}
    ATXN2 -->|"activates"| Parkinson
    NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
    NORMAL_TENSION_GLAUCOMA -->|"associated with"| ATXN2
    CHAT["CHAT"]
    CHAT -->|"associated with"| ATXN2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| ATXN2
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"therapeutic target"| ATXN2
    style ATXN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (264)

Target	Relation	Type	Str
ALS	associated_with	disease	0.95
Tdp-43	suppresses	protein	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
Tdp-43 Toxicity	associated_with	mechanism	0.90
TARDBP	suppresses	gene	0.90
TDP-43 toxicity	suppresses	phenotype	0.90
TDP-43 Pathology	associated_with	phenotype	0.90
lifespan	modulates	phenotype	0.85
TDP-43 Toxicity	modulates	phenotype	0.85
Als Pathogenesis	contributes_to	process	0.85
Motor Neuron Death	involved_in	process	0.85
TDP-43-MEDIATED NEURODEGENERATION	contributes_to	process	0.82
Lifespan	regulates	phenotype	0.80
neurons	expressed_in	cell_type	0.80
STAU1	associated_with	gene	0.80
PINK1	regulates	gene	0.80
Stress Granules	regulates	process	0.80
Motor Neurons	expressed_in	cell_type	0.75
TDP-43	interacts_with	protein	0.75
Als	therapeutic_target	disease	0.75
oxidative stress response	participates_in	pathway	0.70
TDP co-pathology	biomarker_for	phenotype	0.70
neurodegeneration	regulates	disease	0.70
Tdp-43 Proteinopathy	associated_with	phenotype	0.70
neurodegeneration	causes	disease	0.70
ATXN3	causes	gene	0.70
ALS	therapeutic_target	gene	0.70
ALS	interacts_with	disease	0.70
Huntington's disease	causes	disease	0.70
TDP43	interacts_with	protein	0.70
RNP condensate motility	regulates	process	0.70
Ataxia	regulates	disease	0.65
Parkinson	causes	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	expressed_in	disease	0.65
Spinocerebellar Ataxia	regulates	disease	0.65
Ataxia	expressed_in	disease	0.65
Als	treats	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Dementia	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Ms	regulates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Spinocerebellar Ataxia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Ataxia	causes	disease	0.65
Alzheimer	regulates	disease	0.65

Incoming (62)

Source	Relation	Type	Str
Antisense Oligonucleotides	targets	drug	0.85
ALS	associated_with	gene	0.70
ATXN1	causes	gene	0.70
TDP-43	activates	gene	0.60
OPA1	inhibits	gene	0.60
TBC1D24	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
FUS	associated_with	gene	0.60
MTOR	inhibits	gene	0.60
BID	expressed_in	gene	0.60
CCNF	expressed_in	gene	0.60
MAPT	associated_with	gene	0.60
SMN	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
HNRNPA1	associated_with	gene	0.60
CDKN1A	expressed_in	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	treats	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALS	treats	gene	0.60
SOD1 MUTATIONS	treats	gene	0.60
GENES	therapeutic_target	gene	0.60
NEURON	therapeutic_target	gene	0.60
ALS	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
NEURON	causes	gene	0.60
ALS	causes	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
RNA	biomarker_for	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
CHAT	associated_with	gene	0.60
TPRKB	expressed_in	gene	0.60
SOD1	treats	gene	0.60
SOD1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
FUS	co_expressed_with	protein	0.60
PARK7	expressed_in	gene	0.60
PLIN4	encodes	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
levodopa	targets	drug	0.60
ATP13A2	associated_with	gene	0.60
ATXN1	associated_with	gene	0.60
NORMAL TENSION GLAUCOMA	associated_with	gene	0.60
FTLD	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic	0.700	neurodegeneration	How do disease-associated mutations in G
ATXN2 Antisense Oligonucleotides Reduce Dipeptide Repeat Pro	0.630	neurodegeneration	Test

Mentioning Analyses (1)

Scientific analyses that reference this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

closed · Rounds: 4 · Score: 0.76 · 2026-04-28

Related Research

Hypotheses and analyses mentioning ATXN2 in their description or question text

No additional research found

ATXN2

Understanding Entity Pages

Summary

Wiki Pages (4)

ATXN2 Gene

Ataxin-2 (ATXN2)

ATXN2 Protein (Ataxin-2)

Ataxin-2 Protein (ATXN2)

Pathway Diagram

Outgoing (264)

Incoming (62)

Targeting Hypotheses (2)

Mentioning Analyses (1)

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

Experiments (0)

Related Papers (0)

Debates (1)

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

Related Research