Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Prime Editing: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| TDP43-Related Disorders | treats | disease | 0.80 |
| APOE4 | corrects | gene | 0.80 |
| PARKINSON | therapeutic_target | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Prime Editing Precision Correction of APOE4 to APOE3 in Micr | 0.622 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardi [PMID:41276911] | Wang L, Tao X, Zhang N, Yang X, Jiang H | Adv Sci (Weinh) | 2026 | 0 |
| APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associati [PMID:41404739] | Zhang CH, Huang LY, Feng YG, Tan CC, Tan | J Am Heart Assoc | 2026 | 0 |
| High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402] | Du Y, Borné Y, Samuelsson J, Glans I, Hu | Neurology | 2026 | 0 |
| Prime Editing of Alzheimer's Disease High-Risk APOE4 Allele by Brain-Directed Ad [PMID:41449667] | Günaydin C, Hackett NR, Wakim V, Sondhi | Hum Gene Ther | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Endothelial TBK1 Deficiency Inhibits Endothelial-to-Mesenchymal Transition and A [PMID:41685426] | Pu Y, Dong P, He L, Huang J, Wu Y et al. | Circ Res | 2026 | 0 |
| Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246] | Strickland MR, Wang Z, Golden LR, Wang H | J Lipid Res | 2026 | 0 |
| Protective mutations associated with APOE in Alzheimer's disease. [PMID:41703264] | Ma Y, Li Y, Wu G, Liu L, Tian M et al. | Mol Psychiatry | 2026 | 0 |
| HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381] | Hjæresen S, Gramkow ET, Zhang M, Svennin | Prog Neurobiol | 2026 | 0 |
| Trajectories of frailty, grip strength and gait speed preceding dementia: a nest [PMID:41936045] | Wu Z, Phyo AZZ, Cribb L, Vishwanath S, O | Age Ageing | 2026 | 0 |
| Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348] | Shimasaki R, Kurihara M, Bannai T, Hatan | J Prev Alzheimers Dis | 2026 | 0 |
| Apolipoprotein E proteotyping as a valid alternative to genotyping in clinical p [PMID:41940854] | Alcalá Ramírez Del Puerto JM, Ortega-Mad | J Alzheimers Dis | 2026 | 0 |
| Opposing patterns of blood-brain barrier permeability and Alzheimer's disease bi [PMID:41942760] | Bernocchi F, Bonomi CG, Poli M, Di Donna | Neurological sciences : offici | 2026 | 0 |
| Structural MRI phenotyping in Alzheimer's disease: Comparison of visual rating s [PMID:41943971] | Aracki-Trenkic A, Živanović M, Milošević | Biomol Biomed | 2026 | 0 |
| Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis. [PMID:41944070] | Li N, Taherdangkoo K, Baatsch IM, Guduru | Circulation | 2026 | 0 |
| Associations between air pollution and markers of neuroinflammation, synaptic dy [PMID:41944915] | Kimura K, Driscoll I, Cook N, Shahzad S, | Neurotoxicity research | 2026 | 0 |
| A pH-sensitive nanoplatform encapsulating a lipid droplet-specific near-infrared [PMID:41949307] | Zhang Y, Qu T, Wu F, Chen M, Chai Z et a | J Mater Chem B | 2026 | 0 |
| Plant-Based Dietary Patterns and Risk of Alzheimer Disease and Related Dementias [PMID:41950435] | Park SY, Setiawan VW, Crimmins EM, White | Neurology | 2026 | 0 |
| Whole-genome sequencing reveals an East Asian-specific rare variant of INPP5J as [PMID:41951582] | Kimura T, Yamakawa A, Mitsumori R, Niida | Transl Psychiatry | 2026 | 0 |