Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARKINSON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PARKINSON is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 2646 entities in the SciDEX knowledge graph.
| Gene Symbol | PARKINSON |
| Associated Diseases | ALS, Addiction, Aging, Alzheimer, Alzheimer Disease |
| Known Drugs/Compounds | RAPAMYCIN, RESVERATROL, LEVODOPA |
| Interactions | FMR1, RB1CC1, PARL, EIF2S1, NEURODEGENERATIVE DISEASES, ALS |
| KG Connections | 6056 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
PARKINSON["PARKINSON"] -->|"associated with"| ALS["ALS"]
PARKINSON["PARKINSON"] -->|"associated with"| Parkinson["Parkinson"]
PARKINSON["PARKINSON"] -->|"associated with"| CANCER["CANCER"]
PARKINSON["PARKINSON"] -->|"associated with"| AGING["AGING"]
PARKINSON["PARKINSON"] -->|"associated with"| Aging["Aging"]
PARKINSON["PARKINSON"] -->|"associated with"| Alzheimer["Alzheimer"]
PARKINSON["PARKINSON"] -->|"associated with"| Cancer["Cancer"]
PARKINSON["PARKINSON"] -->|"associated with"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated with"| PARKINSON["PARKINSON"]
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| PARKINSON["PARKINSON"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| PARKINSON["PARKINSON"]
end
subgraph Interactions["Interactions"]
PARKINSON["PARKINSON"] -->|"interacts with"| Parkinson_1["Parkinson"]
end
subgraph Signaling["Signaling"]
PARKINSON_S_DISEASE_2["PARKINSON'S DISEASE"] -.->|"inhibits"| PARKINSON["PARKINSON"]
PARKINSON_S_DISEASE_3["PARKINSON'S DISEASE"] -->|"regulates"| PARKINSON["PARKINSON"]
PARKINSON_S_DISEASE_4["PARKINSON'S DISEASE"] -->|"activates"| PARKINSON["PARKINSON"]
end
style PARKINSON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style ALS fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Parkinson fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Parkinson_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CANCER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AGING fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATIVE_DISEASES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Parkinson | interacts_with | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Multiple Sclerosis | associated_with | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Neurodegeneration | causes | disease | 1.00 |
| Aging | causes | disease | 1.00 |
| Huntington | regulates | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| UBIQUITIN | associated_with | gene | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| Parkinson | inhibits | disease | 1.00 |
| Neurodegeneration | contributes_to | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Parkinson | expressed_in | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Parkinson | protects_against | disease | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | causes | gene | 1.00 |
| Neuroinflammation | causes | disease | 1.00 |
| Inflammation | causes | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| NEUROINFLAMMATION | inhibits | gene | 1.00 |
| Neuroinflammation | inhibits | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | inhibits | gene | 1.00 |
| PARKINSON'S DISEASE | regulates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | causes | gene | 1.00 |
| PARKINSON'S DISEASE | contributes_to | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | biomarker_for | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| HUNTINGTON | associated_with | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| NEURODEGENERATION | contributes_to | gene | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| HUNTINGTON | activates | gene | 1.00 |
| NEURODEGENERATION | causes | gene | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| PARKINSON'S DISEASE | implicated_in | gene | 1.00 |
| NEUROTOXICITY | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | inhibits | gene | 1.00 |
| LRRK2 | associated_with | gene | 1.00 |
| NEURODEGENERATION | treats | gene | 1.00 |
| PARKINSON'S DISEASE | treats | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| NEURODEGENERATION | biomarker_for | gene | 1.00 |
| PARKINSON'S DISEASE | interacts_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| HUNTINGTON | regulates | gene | 1.00 |
| HUNTINGTON | causes | gene | 1.00 |
| PARKINSON'S DISEASE | expressed_in | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| HUNTINGTON | implicated_in | gene | 1.00 |
| EXERCISE | activates | gene | 1.00 |
| NEURODEGENERATION | protects_against | gene | 1.00 |
| OXIDATIVE STRESS | implicated_in | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||