mechanism 2,896 words KG: ent-gene-1f51bfd1 2026-03-22
kind:mechanismsection:mechanismsstate:published
Contents

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

🔬 Protein Info
Gene SymbolPINK1
Full NameParkin Mitophagy Pathway in Parkinson's Disease
Chromosome1p36.12
Protein FamilySerine/threonine kinase family
Protein TypeKinase
Functionis a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary ExpressionMitochondrial outer membrane
Molecular Weight63 kDa
PathwaysAmyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt IDQ9BXM7
NCBI Gene ID65018
Ensembl IDENSG00000158828
OMIM608309
GeneCardsPINK1
Human Protein AtlasPINK1
Associated DiseasesAD, ALI, ALS, APOPTOSIS, Aging
Known Drugs/CompoundsDEFERIPRONE, RAPAMYCIN, MELATONIN, propionic acid, Ligustilide, BGP-15
InteractionsBCL2L13, NLRP3, ABCD3, FIP200, RTN3, SESN2
KG Connections3597 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (24)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Mitochondrial Transfer Pathway Enhancement
Score: 0.44
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66

Related Analyses (30)

Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (30)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-1f51bfd1 data_in benchmark_ot_ad_answer_key:PINK1
benchmark_ot_ad_answer_key:PINK1 data_in ent-gene-1f51bfd1