mechanism 3,927 words KG: ent-gene-55fa8e24 2026-03-27
kind:mechanismsection:mechanismsstate:publishedtopic:causal-chaintopic:gb1topic:lysosometopic:parkinson
Contents

GBA1→GCase→Lysosome→PD Causal Chain

🔬 Protein Info
Gene SymbolGBA1
Full NameGlucosylceramidase Beta 1
AliasesGlucocerebrosidase
Chromosome1q21
Protein TypeEnzyme
FunctionLysosomal hydrolase
Molecular Weight52 kDa
Amino Acids497 aa
Exons11
PathwaysAkt, Blood-Brain Barrier, Immune Response, Pi3K
UniProt IDP04062
NCBI Gene ID2629
Ensembl IDENSG00000177693
OMIM606463
GeneCardsGBA1
Human Protein AtlasGBA1
Associated DiseasesALS, Aging, Alzheimer, Cancer, Gaucher Disease
Known Drugs/CompoundsBI-hTFR1, Bi-Htfr1, AAV5, AAV9, levodopa, rapamycin
InteractionsTFRC, LRRK2, JUN, TFR1, SNCA, MLKL
KG Connections434 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Microbial Inflammasome Priming Prevention
Score: 0.58
Smartphone-Detected Motor Variability Correction
Score: 0.56
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56

Related Analyses (30)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (10)

Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90
Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90

Knowledge Graph (2 edges)

ent-gene-55fa8e24 data_in benchmark_ot_ad_answer_key:GBA1
benchmark_ot_ad_answer_key:GBA1 data_in ent-gene-55fa8e24