Exploratory experiment designed to discover new patterns targeting NTN1 in human patient biopsies. Primary outcome: EMT signature reduction and immune infiltrate changes
Comprehensive molecular analysis using bulk RNA sequencing, spatial transcriptomics, and single-cell RNA sequencing on paired pre-treatment and on-treatment biopsies from endometrial carcinoma patients in the NP137 trial. This multi-omics approach aimed to elucidate the mechanism of action of netrin-1 blockade at the molecular level. The analysis revealed a net reduction in tumor EMT signatures, changes in immune infiltrate composition, and increased interactions between cancer cells and the tumor microenvironment, providing mechanistic insights into how NP137 exerts its therapeutic effects.
Bulk RNA-seq, spatial transcriptomics, and single-cell RNA-seq on paired biopsies
Reduced EMT signatures and altered tumor microenvironment
Significant changes in EMT markers and immune cell populations
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