gene 1,010 words KG: RBFOX3 2026-03-24
kind:genesection:genesstate:published
Contents

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

🧬 Gene Info
Gene SymbolRBFOX3
Full NameRNA Binding Fox-3 Homolog (NeuN) (RBFOX3)
AliasesRNA Binding Protein Fox-3
Chromosome17q21.31
Protein TypeGene
FunctionNuclear Localization: Predominantly localizes to the nucleus of most post-mitotic neurons.
Primary Expressionnearly all neurons in the central and peripheral nervous system
UniProt IDQ8WWI5
NCBI Gene ID22998
Ensembl IDENSG00000161981
GeneCardsRBFOX3
Human Protein AtlasRBFOX3
Associated DiseasesRett Syndrome, Intellectual Disability, Epilepsy, Autism Spectrum Disorder
Known Drugs/Compoundsrapamycin
InteractionsWDR45, RNA, AIF1, ARC, CAMKK2, COX4I1
KG Connections57 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
APOE-TREM2 Interaction Modulation
Score: 0.48

Related Analyses (11)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
What determines the specificity of RNA-protein interactions
neurodegeneration · failed
How do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completed
What determines the specificity of DDR protein recruitment t
neurodegeneration · completed
Do chronic stress granule inhibition strategies impair norma
neurodegeneration · failed

Related Experiments (30)

Myricanol treatment in HFD-induced hyperlipidemic C57BL/6J m
validation · proposed · Score: 0.95
Single-cell RNA-seq analysis of mouse testes with gonadal de
exploratory · proposed · Score: 0.95
Sevoflurane-induced neurotoxicity (SIN) rat model
validation · proposed · Score: 0.95
FLS Stimulation and Transcriptomic Analysis
exploratory · proposed · Score: 0.95
Factor depletion effects on DDR focus formation in vivo
exploratory · proposed · Score: 0.90

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

RBFOX3 activates neurodegeneration
RBFOX3 activates WDR45
RBFOX3 participates_in autophagy pathway
RBFOX3 participates_in ubiquitin-proteasome
RBFOX3 activates Alzheimer's disease
RBFOX3 expressed_in neurons
RBFOX3 activates RNA
RBFOX3 activates traumatic brain injury
RBFOX3 activates autism spectrum disorder
AIF1 activates RBFOX3