Validation experiment designed to validate causal mechanisms targeting Cdk5, p35, p39 in mice. Primary outcome: neuronal migration phenotype
Experimental study using mouse models with mutations in Cdk5 or its activators p35 and p39 to investigate their roles in neuronal migration. The research examined how these mutations result in migration phenotypes compatible with defective nucleokinesis, while also potentially affecting leading edge formation. This mouse model system provided controlled experimental conditions to study the molecular mechanisms of neuronal migration defects and validate findings from human genetic studies.
generation and phenotypic analysis of mice with mutations in Cdk5, p35, or p39
mutations would cause defective nucleokinesis and potentially leading edge formation defects
demonstration of migration phenotype consistent with defective nucleokinesis
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