| Gene Symbol | CDK5 |
| Aliases | CDK5PROTEIN |
| Chromosome | 7q36 |
| Protein Family | CMGC kinase group, CDK family |
| Protein Type | Serine/Threonine Kinase |
| Function | Cdk5 knockout mice die at birth with severe cortical layering defects due to failed neuronal migration. |
| Primary Expression | Cytoplasm, nucleus, synapses, growth cones, perinuclear region |
| Amino Acids | 291 aa |
| Pathways | Apoptosis, Autophagy, Checkpoint Inhibitor, Immune Checkpoint, Immune Response |
| GeneCards | CDK5 |
| Human Protein Atlas | CDK5 |
| Phosphorylation Site | AD Relevance |
| Ser202 | Early marker |
| Thr205 | AD-specific |
| Ser396 | Late-stage |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's disease, Ataxia |
| Known Drugs/Compounds | Protopanaxatriol, RESVERATROL, metformin, METFORMIN, N-ACETYLCYSTEINE |
| Interactions | LIS1, DAB1, PAFAH1B1, DRP1, MAPT, HSP90AA1 |
| KG Connections | 612 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |