Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: cognitive Z scores across multiple domains
A prospective cohort study examining associations between dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) exposure and midlife cognitive function among primarily Mexican-born Latina women in an agricultural community in California. The study assessed global and domain-specific cognitive performance in 472 women using serum concentrations of p,p'-DDT and p,p'-DDE measured 12 years earlier. Linear regression models were used to evaluate associations between pesticide concentrations and cognitive Z scores, with Bayesian hierarchical models accounting for co-exposure to other organochlorine pesticides. Apolipoprotein E (APOE) genotype was assessed as a potential modifier of the associations.
Serum p,p'-DDT and p,p'-DDE concentrations measured 12 years prior to cognitive assessment. Cognitive performance evaluated using standardized tests for global and domain-specific function. Linear regression analysis with adjustment for covariates including APOE genotype and organochlorine co-exposures using Bayesian hierarchical models.
Higher pesticide concentrations associated with poorer cognitive function
Statistically significant associations between pesticide exposure and cognitive performance measures
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