| Gene Symbol | APOEPROTEIN |
| Chromosome | 19q13.2 |
| Target Class | Ligand |
| Function | is a 34 kDa secreted glycoprotein that serves as the primary cholesterol transport protein in the brain and plays a central role in lipid metabolism, synaptic repair, and neuroinflammation[@mahley2... |
| Mechanism of Action | Protein-protein interaction modulator or lipid metabolism enhancer |
| Druggability | Medium (0.47) |
| Clinical Stage | Phase II |
| Molecular Weight | 34 kDa |
| GeneCards | APOEPROTEIN |
| Human Protein Atlas | APOEPROTEIN |
| Interactor | Function |
| LDLR | Cholesterol uptake |
| LRP1 | Aβ clearance, signaling |
| APOER2/LRP8 | Reelin signaling, synaptic plasticity |
| [Amyloid-β](proteins/amyloid-beta) | Aggregation, clearance |
| Associated Diseases | AD, AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMI |
| Known Drugs/Compounds | LIPOPROTEINS, Triacylglycerol, Lipid-Targeting Therapeutic Strategies |
| Interactions | LRP1, LDLR, LOX, IL6, SREBF1, PSEN2 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | APOE4-Specific Lipidation Enhancement Therapy Prime Editing Precision Correction of APOE4 to APO Selective APOE4 Degradation via Proteolysis Target (+11 more) |
| KG Connections | 4776 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |