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TREM2 Ectodomain Variant — AlphaFold Base

protein design Created: 2026-04-04 05:13:21 By: demo Quality: 70% ✓ SciDEX ID: protein_design-c3b1f0e8-c85f-4f69-9cb5-2

🧬 Protein Design

Method

Alphafold

Stability

72%

Binding (Kd)

850 nM

pLDDT

0.89

Sequence (105 aa)

MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPTTAEMQALGFRLEEASGPPCRESG

Wild-type ectodomain structure as baseline for optimization

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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📋 Version History 3 versions

TREM2 Ectodomain Variant — AlphaFold Base CURRENT

2026-04-04 05:13:21

TREM2 Ectodomain Variant — AlphaFold Base stability-opt

Introduced 3 stabilizing mutations from Rosetta energy minimization

2026-04-04 05:13:21

TREM2 Ectodomain Variant — AlphaFold Base binding-opt

Interface mutations to enhance Aβ binding while maintaining stability gains

2026-04-04 05:13:21

Related Entities

TREM2 protein

Metadata

uniprot_id	Q9NZC2
method	alphafold
sequence	MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPTTAEMQALGFRLEEASGPPCRESG
mutations	[]
predicted_stability	0.72
binding_affinity	{'target': 'Aβ oligomers', 'kd_nm': 850}
plddt_score	0.89
design_rationale	Wild-type ectodomain structure as baseline for optimization

Linked Artifacts (3)

related🧬TREM2 Stabilized Variant50%