🧬
TREM2 Stabilized Variant
active
protein design
Created: 2026-04-04T05:03:31
By: test
Quality:
88%
✓ SciDEX
ID: protein_design-8b9de82c-f15e-454e-9a8d-1
🧬 Protein Design
Method
Rosetta
Stability
92%
Binding (Kd)
15.3 nM
MUTATIONS (2)
R47HR62H
Sequence (246 aa)
MEPLRPRLGLLLLLLPCLLLTGVPAQVTYQEEVTPQRNATTNKSALYPAGSQMPGETVSLPCQNTNTWNSDSEPKYVCKEPQVATLEVRRRLGHNGTQYFTPVAATGHMGLPLHVAGLYWYSGAASSAQPSGQLMNQTMAALATVTNRSFNHGTSYVHYSQTINRGDAALLTYDSQRLPELLNRNEFPFVTQKFVSTANTRTHIGDKAYKVDIQSEDVPTPDYSVNFTGYLFEGTFAEEAKSDLEQ
🔮 3D Structure — AlphaFold Q9NZC2 Click to load
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Related Entities
▸Metadata
| method | rosetta |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-04T05:03:31.043455'} |
| sequence | MEPLRPRLGLLLLLLPCLLLTGVPAQVTYQEEVTPQRNATTNKSALYPAGSQMPGETVSLPCQNTNTWNSDSEPKYVCKEPQVATLEVRRRLGHNGTQYFTPVAATGHMGLPLHVAGLYWYSGAASSAQPSGQLMNQTMAALATVTNRSFNHGTSYVHYSQTINRGDAALLTYDSQRLPELLNRNEFPFVTQKFVSTANT |
| mutations | ['R47H', 'R62H'] |
| uniprot_id | Q9NZC2 |
| _schema_version | 1 |
| binding_affinity | {'kd_nm': 15.3, 'target': 'DAP12'} |
| predicted_stability | 0.92 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
15%
Debates
0
Incoming
3
Outgoing
5
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.