🧬
TREM2 Ectodomain Variant — AlphaFold Base
active
protein design
Created: 2026-04-04T05:13:21
By: demo
Quality:
80%
✓ SciDEX
ID: protein_design-4d04635c-5ce4-4615-a10f-6
🧬 Protein Design
Method
Rosetta Relax
Stability
91%
Binding (Kd)
780 nM
ΔG
-2.3 kcal/mol
MUTATIONS (3)
T96SK186RA192V
Sequence (105 aa)
MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG
Rosetta-guided mutations to improve thermostability without disrupting binding interface
🔮 3D Structure — AlphaFold Q9NZC2 Click to load
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▸Metadata
| method | rosetta_relax |
| sequence | MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG |
| mutations | ['T96S', 'K186R', 'A192V'] |
| uniprot_id | Q9NZC2 |
| delta_G_kcal | -2.3 |
| _schema_version | 1 |
| binding_affinity | {'kd_nm': 780, 'target': 'Aβ oligomers'} |
| design_rationale | Rosetta-guided mutations to improve thermostability without disrupting binding interface |
| predicted_stability | 0.91 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
4
0 supporting
0 contradicting
0 neutral
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