Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| secondary structure | involved_in | process | 0.95 |
| protein folding | involved_in | process | 0.95 |
| amino acid sequence | involved_in | process | 0.90 |
| protein_quantitative_trait_loci | mediates | phenotype | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEMO | interacts_with | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 | 0.601 | neurodegeneration | What are the mechanisms by which gut mic |
| Heat Shock Protein 70 Disaggregase Amplification | 0.511 | neurodegeneration | TDP-43 phase separation therapeutics for |
| Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides | 0.509 | neurodegeneration | Blood-brain barrier transport mechanisms |
| Conditional CRISPR Kill Switches for Aberrant Protein Cleara | 0.451 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Serine/Arginine-Rich Protein Kinase Modulation | 0.423 | neurodegeneration | TDP-43 phase separation therapeutics for |
| Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m | 0.348 | neurodegeneration | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.548
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress [PMID:40066224] | Liu H, Zhou Y, Wang Z, Liu D, Li Y, Lai | MedComm (2020) | 2025 | 1 |
| From sleep to cancer to neurodegenerative disease: the crucial role of Hsp70 in [PMID:37643058] | Ghosh S, Vashisth K, Ghosh S, Han SS, Bh | J Biomol Struct Dyn | 2024 | 1 |
| Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteom [PMID:37652020] | Yuan S, Xu F, Li X, Chen J, Zheng J, Man | Cell Rep Med | 2023 | 1 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. [PMID:36348357] | Raulin AC, Doss SV, Trottier ZA, Ikezu T | Mol Neurodegener | 2022 | 1 |
| DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-asso [PMID:34614409] | Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, | Cell Metab | 2021 | 1 |
| Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216] | Banik SM, Pedram K, Wisnovsky S, Ahn G, | Nature | 2020 | 1 |
| Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kin [PMID:32169215] | Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, W | Cell | 2020 | 1 |
| Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventin [PMID:30595089] | Brophy ML, Dong Y, Tao H, Yancey PG, Son | Circ Res | 2019 | 1 |
| KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745] | Rydzanicz M, Jagła M, Kosinska J, Tomasi | Clin Genet | 2017 | 1 |
| Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical [PMID:28381441] | Shinohara M, Tachibana M, Kanekiyo T, Bu | J Lipid Res | 2017 | 1 |
| TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375] | van Spronsen M, Mikhaylova M, Lipka J, S | Neuron | 2013 | 1 |
| Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670] | Randall TS, Moores C, Stephenson FA | FEBS Lett | 2013 | 1 |
| ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fert [PMID:23177736] | Zheng G, Dahl JA, Niu Y, Fedorcsak P, Hu | Mol Cell | 2013 | 1 |
| Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancie [PMID:19821156] | Molvarec A, Tamási L, Losonczy G, Madách | Cell Stress Chaperones | 2010 | 1 |
| Integrating NHANES and network toxicology to assess the impact of organophosphat [PMID:41804832] | Dai K, Huang Y, Cai H, Zhong G, Xie Z, W | Toxicology mechanisms and meth | 2026 | 0 |
| Crystal structures reveal phosphorylation-dependent disruption of the heat shock [PMID:41833837] | Stewart M, Paththamperuma C, McCann C, C | Cell stress & chaperones | 2026 | 0 |
| Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbat [PMID:41725010] | Wen M, Li J, Li Y, Hun M, Yang T, Meng Y | Cell & bioscience | 2026 | 0 |
| Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via ne [PMID:41539636] | ["Fu X", "Long Q", "Wang Z", "Yan S", "L | Journal of ethnopharmacology | 2026 | 0 |
| Single-cell transcriptomics reveal heat shock protein dysregulation in severe SA [PMID:41772029] | Suzuki T, Sato Y, Suzuki M, Fukuda Y, Iw | Scientific reports | 2026 | 0 |