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TREM2 Ectodomain Variant — AlphaFold Base

protein design Created: 2026-04-04 05:13:21 By: demo Quality: 92% ✓ SciDEX ID: protein_design-05748b75-8d32-47b4-9981-2

🧬 Protein Design

Method

Rosetta Interface Design

Stability

88%

Binding (Kd)

120 nM

ΔG

-1.8 kcal/mol

MUTATIONS (5)

T96SK186RA192VH157YR62W

Sequence (105 aa)

MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNSCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG

Interface residue optimization for enhanced Aβ oligomer recognition. Slight stability trade-off accepted for 6.5x binding improvement.

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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📋 Version History 3 versions

TREM2 Ectodomain Variant — AlphaFold Base

2026-04-04 05:13:21

TREM2 Ectodomain Variant — AlphaFold Base stability-opt

Introduced 3 stabilizing mutations from Rosetta energy minimization

2026-04-04 05:13:21

TREM2 Ectodomain Variant — AlphaFold Base binding-opt CURRENT

Interface mutations to enhance Aβ binding while maintaining stability gains

2026-04-04 05:13:21

Related Entities

TREM2 protein

Metadata

uniprot_id	Q9NZC2
method	rosetta_interface_design
sequence	MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNSCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG
mutations	['T96S', 'K186R', 'A192V', 'H157Y', 'R62W']
predicted_stability	0.88
binding_affinity	{'target': 'Aβ oligomers', 'kd_nm': 120}
delta_G_kcal	-1.8
design_rationale	Interface residue optimization for enhanced Aβ oligomer recognition. Slight stability trade-off accepted for 6.5x binding improvement.

Linked Artifacts (7)

related🧬TREM2 Stabilized Variant50%