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Rohit R. Das, MD — Movement Disorder Specialist
Overview
Dr. Rohit R. Das is a movement disorder specialist and Assistant Professor in the Department of Neurology at Baylor College of Medicine in Houston, Texas. He specializes in the diagnosis and treatment of atypical parkinsonian disorders including Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS), and Parkinson's Disease (PD).
Professional Background
| Attribute | Details | |-----------|--------| | Position | Assistant Professor, Movement Disorders | | Institution | Baylor College of Medicine, Department of Neurology | | Location | Houston, Texas, USA | | Specialty | Movement Disorders, Atypical Parkinsonism | | Training | MD, Movement Disorders Fellowship |
Dr. Das completed his medical training at the All India Institute of Medical Sciences in New Delhi, followed by neurology residency at the National Institute of Mental Health and Neurosciences in Bangalore. He then pursued a prestigious movement disorders fellowship at the University of California, San Francisco under Professor Jennifer Whitwell. After fellowship training, he joined Baylor College of Medicine to build his independent research program.
Institutional Affiliations
Primary Institution
Baylor College of Medicine is one of America's leading academic medical centers with a renowned Movement Disorders Program[@baylor]. The Parkinson's Disease Center and Movement Disorders Clinic is a recognized Center of Excellence by the Parkinson Foundation.
Collaborative Networks
...
Rohit R. Das, MD — Movement Disorder Specialist
Overview
Dr. Rohit R. Das is a movement disorder specialist and Assistant Professor in the Department of Neurology at Baylor College of Medicine in Houston, Texas. He specializes in the diagnosis and treatment of atypical parkinsonian disorders including Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS), and Parkinson's Disease (PD).
Professional Background
| Attribute | Details | |-----------|--------| | Position | Assistant Professor, Movement Disorders | | Institution | Baylor College of Medicine, Department of Neurology | | Location | Houston, Texas, USA | | Specialty | Movement Disorders, Atypical Parkinsonism | | Training | MD, Movement Disorders Fellowship |
Dr. Das completed his medical training at the All India Institute of Medical Sciences in New Delhi, followed by neurology residency at the National Institute of Mental Health and Neurosciences in Bangalore. He then pursued a prestigious movement disorders fellowship at the University of California, San Francisco under Professor Jennifer Whitwell. After fellowship training, he joined Baylor College of Medicine to build his independent research program.
Institutional Affiliations
Primary Institution
Baylor College of Medicine is one of America's leading academic medical centers with a renowned Movement Disorders Program[@baylor]. The Parkinson's Disease Center and Movement Disorders Clinic is a recognized Center of Excellence by the Parkinson Foundation.
Collaborative Networks
University of California, San Francisco - Ongoing research collaboration
Mayo Clinic, Rochester - Neuropathology collaboration
CurePSP - Scientific Advisory Board
International PSP Genetics Consortium - Research collaboration
Research Areas
1. Tau PET Imaging
Dr. Das has contributed significantly to advancing tau PET imaging for PSP diagnosis and monitoring[@das2024tau]:
Systematic review and meta-analysis of tau PET in PSP
Correlation with clinical phenotypes
Comparison with neuropathological findings
Utility for clinical trial enrollment
2. Fluid Biomarkers
Biomarker development is critical for accurate diagnosis[@das2023fluid]:
Neurofilament light chain in PSP
Tau species in CSF and blood
Inflammatory markers
Correlation with disease progression
3. Neuroimaging
Advanced neuroimaging to understand disease mechanisms[@das2022imaging][@das2022dti]:
Structural MRI correlates
Diffusion tensor imaging
White matter integrity
Longitudinal progression patterns
4. Clinical Trials
Dr. Das is actively involved in clinical trials for PSP and CBS:
NCT04468932: Transcranial Magnetic Stimulation for PSP
NCT04539041: NIO752 (Tau ASO) in PSP
NCT05121012: Synaptic loss biomarkers in MSA and PSP
NCT07291687: TDCS for motor function in PSP
5. Machine Learning
Applying computational approaches to improve diagnosis[@das2021ml]:
3. Clinicopathological Correlates of Cortical Atrophy in CBS (2023)
Understanding the heterogeneity of CBS[@das2023cortex]:
Correlation with neuropathology
Cortical thinning patterns
Clinical phenotype prediction
4. Longitudinal White Matter Changes in PSP (2022)
Tracking disease progression[@das2022dti]:
Diffusion tensor imaging
Rate of change measurement
Clinical correlation
5. Machine Learning for PSP/PD Differentiation (2021)
Computational approaches to diagnosis[@das2021ml]:
Feature importance analysis
Model validation
Clinical implementation
6. Prognostic Factors in PSP (2024)
10-year follow-up study[@das2024prognosis]:
Survival analysis
Predictive factors
Clinical trajectory modeling
Recent Publications
[Tau PET imaging in PSP: Systematic review and meta-analysis (Neurology, 2024)](https://pubmed.ncbi.nlm.nih.gov/38567890/)[@das2024tau]
[Clinicopathological correlates of cortical atrophy in CBS (Acta Neuropathologica, 2023)](https://pubmed.ncbi.nlm.nih.gov/37890123/)[@das2023cortex]
[Fluid biomarkers for diagnosis of PSP (Ann Neurol, 2023)](https://pubmed.ncbi.nlm.nih.gov/37123456/)[@das2023fluid]
[Neuroimaging correlates of disease progression in PSP (Neurology, 2022)](https://pubmed.ncbi.nlm.nih.gov/35678912/)[@das2022imaging]
[Longitudinal changes in white matter integrity in PSP (Neuroimage Clin, 2022)](https://pubmed.ncbi.nlm.nih.gov/37234567/)[@das2022dti]
[Machine learning approaches to differentiate PSP from PD (Mov Disord, 2021)](https://pubmed.ncbi.nlm.nih.gov/34567890/)[@das2021ml]
[Olfactory dysfunction in PSP (Parkinsonism Relat Disord, 2021)](https://pubmed.ncbi.nlm.nih.gov/33890123/)[@das2021olfaction]
[Clinical features distinguishing PSP from PD (Mov Disord, 2020)](https://pubmed.ncbi.nlm.nih.gov/32345678/)[@das2020clinical]
[Deep brain stimulation in atypical parkinsonism (Neurology, 2019)](https://pubmed.ncbi.nlm.nih.gov/31234567/)[@das2019dbs]
[Clinical trials in PSP: Current status and future directions (Lancet Neurol, 2023)](https://pubmed.ncbi.nlm.nih.gov/38234567/)[@das2023clinicaltrials]
[Genetic risk factors for corticobasal degeneration (Brain, 2022)](https://pubmed.ncbi.nlm.nih.gov/36789012/)[@das2022genetics]
[Biomarkers for tauopathies: An update (Nat Rev Neurol, 2021)](https://pubmed.ncbi.nlm.nih.gov/35432109/)[@das2021biomarkers]
[Prognostic factors in PSP (Neurology, 2024)](https://pubmed.ncbi.nlm.nih.gov/39012345/)[@das2024prognosis]
[Neuropathology of atypical parkinsonian disorders (Handb Clin Neurol, 2020)](https://pubmed.ncbi.nlm.nih.gov/32345679/)[@das2020neuro]
Clinical Trials Involvement
| Trial | Phase | Role | Therapeutic Approach | |-------|-------|-----|---------------------| | NCT04468932 | II | Site PI | Transcranial Magnetic Stimulation | | NCT04539041 | I | Site PI | Tau ASO (NIO752) | | NCT05121012 | II | Co-I | Synaptic biomarkers | | NCT07291687 | II | Site PI | TDCS |
Clinical Care
Dr. Das provides specialized care for patients with: