Perforant Path Presynaptic Terminal Protection Strategy

**Molecular Mechanism and Rationale** The perforant path represents one of the most metabolically demanding neuronal projections in the central nervous system, consisting of exceptionally long axons extending from layer II stellate neurons in the entorhinal cortex (EC) to granule cells in the hippocampal dentate gyrus. These axons can span distances exceeding 10 millimeters in humans, requiring robust mitochondrial networks and efficient ATP production to maintain synaptic transmission and axon...