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Progressive Supranuclear Palsy (PSP)

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-diseases-psp
Related Entities
PSP
Metadata
slugdiseases-psp
entity_typedisease
kg_node_idPSP
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (191)
mentions🧫4R-Tau Targeting Therapies for PSP and CBS90%
mentions🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri90%
mentions🧫Brainstem Circuit Modulation for PSP90%
mentions🧫Levodopa Response Determinants in PSP — Biomarker-Guided Pre90%
mentions🧫PSP and CBS Biomarker Validation Study90%
mentions🧫Tau Pathology Initiation Zone Identification90%
mentions🧫Tau Spreading Network Mapping via Spatial Transcriptomics in90%
mentions🧫4R-Tau Targeting Therapies for PSP and CBS70%
mentions🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri70%
mentions🧫Brainstem Circuit Modulation for PSP70%
mentions🧫Levodopa Response Determinants in PSP — Biomarker-Guided Pre70%
mentions🧫PSP and CBS Biomarker Validation Study70%
mentions🧫Tau Pathology Initiation Zone Identification70%
mentions🧫Tau Spreading Network Mapping via Spatial Transcriptomics in70%
related🧫4R-Tau Targeting Therapies for PSP and CBS70%
related🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri70%
related🧫Brainstem Circuit Modulation for PSP70%
related🧫Levodopa Response Determinants in PSP — Biomarker-Guided Pre70%
related🧫PSP and CBS Biomarker Validation Study70%
related🧫Tau Pathology Initiation Zone Identification70%
related🧫Tau Spreading Network Mapping via Spatial Transcriptomics in70%
mentions🧪Microglial Purinergic Reprogramming65%
mentions🧪Glial Glycocalyx Remodeling Therapy65%
mentions🧪Ephrin-B2/EphB4 Axis Manipulation65%
mentions🧪Trans-Synaptic Adhesion Molecule Modulation65%
related🧫4R-Tau Targeting Therapies for PSP and CBS63%
related🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri63%
related🧫Brainstem Circuit Modulation for PSP63%
related🧫Levodopa Response Determinants in PSP — Biomarker-Guided Pre63%
related🧫PSP and CBS Biomarker Validation Study63%
related🧫Tau Pathology Initiation Zone Identification63%
related🧫Tau Spreading Network Mapping via Spatial Transcriptomics in63%
mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp60%
mentions🔬PSP and CBD both involve 4R-tau but produce distinct neuropa60%
mentions🧫s:** - Test tau spreading in AQP4 knockout vs wild-type mice60%
mentions🧫Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy60%
mentions🧫CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi60%
mentions🧫CRISPR Gene Correction Approaches for CBS/PSP60%
mentions🧫N-of-1 Clinical Trial Design for CBS/PSP60%
mentions🧫Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo60%
related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr60%
related🧫Metabolic Pathway-Targeted Therapy in ALS60%
related🧫ALS Progression Rate Heterogeneity — mechanism and biomarker60%
related🧫ALS Regional Onset and Spread: Network-Level Staging Model60%
related🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk60%
related🧫Blood Biomarker vs Tau PET for Treatment Monitoring60%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT60%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study60%
related🧫Environmental Exposure Causal Attribution in ALS — Experimen60%
related🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio60%
related🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design60%
related🧫N-of-1 Clinical Trial Design for CBS/PSP60%
related🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers60%
related🧫Pre-Symptomatic Detection and Intervention Timing in Genetic60%
related🧫Progranulin Replacement Therapy for FTD — Vector Development60%
related🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD60%
related🧫Sleep and Respiratory Network Interaction in ALS — Experimen60%
related🧫TDP-43 PET Ligand Development for FTD and ALS60%
related🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des60%
see_also📖Genes60%
see_also📖VPS29 Gene60%
see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%
see_also📖Frontotemporal Dementia (FTD)60%
see_also📖Apoptosis in Neurodegeneration60%
see_also📖cdkn2a60%
see_also📖DUSP10 Gene60%
see_also📖KIF13A Gene60%
see_also📖MAP1S - Microtubule Associated Protein 1S60%
see_also📖STX6 Gene60%
see_also📖TRIM24 — Tripartite Motif Containing 2460%
see_also📖Alzheimer Indonesia60%
see_also📖Dementia Australia60%
see_also📖diseases-amyotrophic-lateral-sclerosis60%
see_also📖Packard Center for ALS Research60%
see_also📖Autophagy Enhancement Drug Screening for Neurodegeneration60%
related🧪Microglial Purinergic Reprogramming58%
related🧪Glial Glycocalyx Remodeling Therapy58%
related🧪Ephrin-B2/EphB4 Axis Manipulation58%
related🧪Trans-Synaptic Adhesion Molecule Modulation58%
mentions🧫s:** - Single-cell RNA-seq to measure editing efficiency acr55%
mentions🧫Metabolic Pathway-Targeted Therapy in ALS55%
mentions🧫ALS Progression Rate Heterogeneity — mechanism and biomarker55%
mentions🧫ALS Regional Onset and Spread: Network-Level Staging Model55%
mentions🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk55%
mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT55%
mentions🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study55%
mentions🧫Environmental Exposure Causal Attribution in ALS — Experimen55%
mentions🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio55%
mentions🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design55%
mentions🧫Pre-Symptomatic Detection and Intervention Timing in Genetic55%
mentions🧫Progranulin Replacement Therapy for FTD — Vector Development55%
mentions🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD55%
mentions🧫Sleep and Respiratory Network Interaction in ALS — Experimen55%
mentions🧫TDP-43 PET Ligand Development for FTD and ALS55%
mentions🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des55%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp54%
related🔬PSP and CBD both involve 4R-tau but produce distinct neuropa54%
related🧫s:** - Test tau spreading in AQP4 knockout vs wild-type mice54%
related🧫Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy54%
related🧫CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi54%
related🧫CRISPR Gene Correction Approaches for CBS/PSP54%
related🧫N-of-1 Clinical Trial Design for CBS/PSP54%
related🧫Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo54%
related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr54%
related🧫Metabolic Pathway-Targeted Therapy in ALS54%
related🧫ALS Progression Rate Heterogeneity — mechanism and biomarker54%
related🧫ALS Regional Onset and Spread: Network-Level Staging Model54%
related🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk54%
related🧫Blood Biomarker vs Tau PET for Treatment Monitoring54%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT54%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study54%
related🧫Environmental Exposure Causal Attribution in ALS — Experimen54%
related🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio54%
related🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design54%
related🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers54%
related🧫Pre-Symptomatic Detection and Intervention Timing in Genetic54%
related🧫Progranulin Replacement Therapy for FTD — Vector Development54%
related🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD54%
related🧫Sleep and Respiratory Network Interaction in ALS — Experimen54%
related🧫TDP-43 PET Ligand Development for FTD and ALS54%
related🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des54%
mentions🧫iPSC-NPC effects on astrocytes in vitro ICH model50%
mentions🧫Blood Biomarker vs Tau PET for Treatment Monitoring50%
mentions🧫Microtubule domain analysis in adult axons50%
mentions🧫Tau depletion effects on neuronal development in primary cul50%
mentions🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers50%
mentions🧫Nrf2 inhibitor ML385 mechanism validation experiment50%
mentions🧫Acteoside treatment in LPS-induced SALI mouse model50%
mentions🧫Acteoside effects on RAW264.7 macrophage cells50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
mentions🧪Axonal RNA Transport Reconstitution50%
mentions🧪APOE-Dependent Autophagy Restoration50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying protein aggregation cross50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬How does metabolic reprogramming (glucose metabolism shifts,50%
related🧪Piezoelectric Nanochannel BBB Disruption50%
related🧪Retinal Vascular Microcirculation Rescue50%
related🧪Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat50%
related🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%
related🧪Oligodendrocyte White Matter Vulnerability50%
related🧪Multi-Modal Stress Response Harmonization50%
mentions📖AAIC 2026: Tau Immunotherapy40%
mentions📖Adam L. Boxer40%
mentions📖Alexei Mikhailov40%
mentions📖Angelo Antonini, MD, PhD — Movement Disorder Specialist40%
mentions📖Bradley F. Boeve40%
mentions📖Brian Roels — PSP Neuropathology Researcher40%
mentions📖CIEN Foundation40%
mentions📖Chiara Marsili — PSP Researcher40%
mentions📖CurePSP - Foundation for Progressive Supranuclear Palsy40%
mentions📖CurePSP — International PSP Foundation40%
mentions📖David Irwin40%
mentions📖Eduardo Tolosa — PSP Researcher40%
mentions📖Ferrer Internacional40%
mentions📖Günter Höglinger40%
mentions📖Hirofumi Yoshino — Tauopathy Researcher40%
mentions📖Huw Morris40%
mentions📖Irene Litvan40%
mentions📖James Leverenz40%
mentions📖James Rowe40%
mentions📖John E. Duda — Neuropathology Researcher40%
mentions📖John R. Hodges40%
mentions📖Kailash Bhatia40%
mentions📖Lauren Shore40%
mentions📖Lawrence Golbe40%
mentions📖Marc H. Smith40%
mentions📖Maria Bernardino — PSP Researcher40%
mentions📖Masahiro Kato — PSP Researcher40%
mentions📖Nicola Ray — Movement Disorder Researcher40%
mentions📖Nicolas Lambrecq40%
mentions📖Oligomerix, Inc.40%
mentions📖Pinteon40%
mentions📖Reo40%
mentions📖Rohit Das — Movement Disorder Specialist40%
mentions📖Tetsuya Kimura40%
mentions📖Werner Poewe — International Movement Disorder Expert40%
mentions📖uni-washington40%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa40%
mentions🔬What are the mechanisms underlying protein aggregation cross40%
mentions🔬How does metabolic reprogramming (glucose metabolism shifts,40%
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