🧫
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-er-golgi
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.903679Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['ER'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design ## Background and Rationale This clinical validation study investigates endoplasmic reticulum (ER) and Golgi apparatus dysfunction as |
| replication_status | single_study |
| methodology_notes | **Phase 1: Patient Recruitment and Characterization (Months 1-3)** • Recruit 150 participants: 75 PD patients (H&Y stages 1-3) and 75 age-matched healthy controls • Confirm PD diagnosis using MDS clin |
| primary_outcome | Quantitative assessment of ER stress marker expression (BiP, phospho-eIF2α, spliced XBP1) in patient-derived skin fibroblasts compared to healthy controls, with correlation to disease severity measure |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.903686'} |
Linked Artifacts (12567)